Hexapeptide-33 Zambiri za Chemical Chemical

Dzina La Munda	Zambiri
Dzina la INCI	Hexapeptide-33
CHO	1192135-40-2
Mafananidwe	Hexapeptide-33; W3 peptide; Ser-Phe-Lys-Leu-Arg-Tyr-NH2; SFKLRY
Ubwino chinsinsi	Kuletsa utoto/Kuwala

Hexapeptide-33 Kufotokozera Ufa

Dzina La Munda	Zambiri
fomu	Powder
Maonekedwe	Yoyera mpaka wofiira
Purity (HPLC)	≥ 95.0%, kapena ≥ 98.0%
Zosunga	Sungani motsekedwa, motetezedwa ku kuwala ndi chinyezi. Sungani kwa nthawi yayitali pa -20°C.
CD	Mabotolo agalasi/pulasitiki, kapena mapaketi okonzedwa mwamakonda kutengera zopempha zapadera.
Manyamulidwe	Kunyamula katundu woyenda mumlengalenga mothamanga komanso motetezeka ku chinyezi.
Kufufuza	[Pemphani Mtengo / Zitsanzo za Oda]

Hexapeptide-33 Kufotokozera kwa Yankho

Dzina La Munda	Tsatanetsatane
fomu	Zamadzi
Maonekedwe	Chotsani Chowonekera Madzi
Zinthu za Peptide	500ppm – 1000ppm (Zosinthika)
Zosunga	Ikhoza kunyamulidwa kutentha kwa chipinda. Sungani pamalo ouma, amdima pa 2-8°C kuti musunge kwa nthawi yayitali.
CD	1Kg kapena 5kg, kapena ma phukusi osinthidwa malinga ndi zopempha zapadera.
Kufufuza	[Pemphani Mtengo / Zitsanzo za Oda]

Hexapeptide-33 imaletsa zoyambitsa melanin kudzera mu GPCR antagonism, imaletsa tyrosinase, komanso imaletsa PIH kuti khungu liwoneke bwino kwambiri.

Ubwino ndi Phindu

mbali	tsatanetsatane
Kuzindikira Zizindikiro	Imagwira ntchito ngati wotsutsa wa GPCR poletsa α-MSH, chizindikiro chachikulu cha "kuyamba" kwa melanin.
Tyrosinase Inhibition	Amachepetsa mwachindunji ntchito ya tyrosinase kuti alepheretse kusintha kwa DOPA kukhala melanin.
Kupewa kwa PIH	Zimathandiza kwambiri pochepetsa zizindikiro za kupsinjika zomwe zimayambitsa hyperpigmentation pambuyo pa kutupa.
Kuwala Molondola	Imayang'ana malo amdima ndi khungu losafanana bwino pogwiritsa ntchito njira yodziwira bwino momwe opaleshoni imachitikira pamlingo wa mamolekyulu.
Mbiri Yachitetezo	Njira yoyeretsa khungu yopanda poizoni yomwe imawunikira khungu popanda kuwononga thanzi la melanocyte.

Ibibazo

Q1: Kodi njira yomwe Hexapeptide-33 (SFKLRY-NH₂) imaperekera ubwino woteteza khungu ku utoto ndi iti, ndipo ndi umboni wotani womwe umatsimikizira izi mu labotale?

A :Hexapeptide-33 (sequence Ser‑Phe‑Lys‑Leu‑Arg‑Tyr‑NH₂) imaletsa kupanga melanin kudzera m'njira ziwiri zotsatizana. Imagwira ntchito ngati choletsa mwachindunji cha tyrosinase, kuchepetsa kupanga melanin m'maselo a melanoma a B16. Kuphatikiza apo, imagwira ntchito ngati endothelin‑1 receptor antagonist, kuletsa chizindikiro cha ET‑1 chomwe chimalimbikitsa melanogenesis. Mu vitro, imachepetsa kupanga melanin ndi 40% ndikuchepetsa kuchuluka kwa mapuloteni a tyrosinase m'maselo a B16. Kafukufuku wa 2009 (Lee et al., Int J Pept Res Ther 15:281–286) adayamba kufotokoza za mphamvu izi zotsutsana ndi melanin komanso antioxidant za peptide iyi.

Q2: Kodi Hexapeptide-33 imaletsa bwanji melanin popanda kuuma kwa ma acid achikhalidwe?

A: Mosiyana ndi AHAs kapena Vitamini C zomwe zimatha kukwiyitsa, Hexapeptide-33 ndi Biomimetic Signal Blocker . Imayang'ana ma GPCRs (G-Protein-Coupled Receptors) pa ma melanocytes kuti isokoneze "lamulo la danning." Mwa kuletsa kufalikira kwa zizindikiro zomwe zimapangitsa kuti melanin ipangidwe, imapeza mphamvu yowala kwambiri pomwe imakhalabe yotonthoza komanso yotetezeka pakhungu lofewa.

Q3: Kodi imayang'ana kwambiri Post-Inflammatory Hyperpigmentation (PIH)?

A: Apa ndi pomwe Hexapeptide-33 imaonekera bwino. Chifukwa cha cholowa chake cha "kukonza mabala" , ndi yothandiza kwambiri popewa ndikutha PIH (malo amdima omwe amasiyidwa ndi ziphuphu kapena njira zochizira). Imaletsa zizindikiro zotupa zomwe nthawi zambiri zimayambitsa melanocytes kupanga utoto wochulukirapo, ndikuwonetsetsa kuti khungu lokonzedwalo limachira ndi mawonekedwe omveka bwino komanso ofanana.

Q4: Kodi Hexapeptide-33 ingathetse mawanga akuda omwe alipo komanso khungu losafanana?

A: Inde. Mwa kuletsa nthawi zonse kupanga melanin yatsopano ndikulimbikitsa kusintha kwa keratinocyte, kumateteza mawanga omwe alipo kuti asadetsedwe pomwe kumalola khungu kutulutsa maselo okhala ndi utoto mwachibadwa. Izi zimapangitsa kuti "kuwala padziko lonse" kuwonekere komanso khungu likhale lowala komanso lofanana.

Q5: Kodi imagwirizana ndi mankhwala ena oyeretsa khungu monga Niacinamide kapena Tranexamic Acid?

A: Ndi mgwirizano wabwino kwambiri . Ngakhale kuti Niacinamide imaletsa kusamutsa melanin ndipo Tranexamic Acid imalunjika ku plasmin , Hexapeptide-33 imagwira ntchito pachiyambi cha chizindikiro . Kuphatikizana kumeneku kumapanga chitetezo chamitundu yambiri ku hyperpigmentation, chomwe chimaphimba sitepe iliyonse kuyambira "chizindikiro" mpaka "madontho".

Q6: N’chifukwa chiyani amalimbikitsidwa kuyeretsa khungu la “After-Sun” kapena “Post-Laser”?

A: Kuwonetsedwa ndi UV ndi chithandizo cha laser zimayambitsa kutulutsidwa kwakukulu kwa α-MSH (hormone yolimbikitsa melanocyte). Hexapeptide-33 imagwira ntchito ngati chishango cha molekyulu, kuletsa zizindikiro za kupsinjika zomwe zimayambitsa "kubwereranso" kwa utoto. Ndi chinthu chabwino kwambiri chowonetsetsa kuti khungu limakhalabe lowala pambuyo poti lasokonezedwa ndi zinthu zina zakunja.