I-Hexapeptide-33 Ulwazi olusisiseko lweMichiza

Igama lendawo	Ulwazi olusisiseko
INCI Igama	I-Hexapeptide-33
Inombolo yeCAS	1192135-40-2
Iintetho ezifanayo	IHexapeptide-33; iW3 peptide ; I-Ser-Phe-Lys-Leu-Arg-Tyr-NH2; SFKLRY
IziBonelelo eziPhambili	Ukuchasana nombala/Ukukhanya

I-Hexapeptide-33 Ukucaciswa komgubo

Igama lendawo	Ulwazi olusisiseko
imo	Umda
Kubonakala	Umhlophe ukuya kutsho-omhlophe
Ucoceko (HPLC)	≥ 95.0%, okanye ≥ 98.0%
Imiqathango yoGcino	Gcina ivaliwe, ikhuselekile ekukhanyeni nasekufumeni. Kucetyiswa ukuba igcinwe ixesha elide kwi -20°C.
Packaging	Iibhotile zeglasi/zeplastiki zesampulu, okanye iipakethe ezenziwe ngokwezifiso ezisekelwe kwizicelo ezikhethekileyo.
Ukuhambisa ngenqanawe	Ukuhambisa umoya ngokukhawuleza kunye nokhuseleko olungenamswakama.
uphando	[Cela iNgqikelelo / iiSampuli ze-odolo]

I-Hexapeptide-33 Inkcazo yeSisombululo

Igama lendawo	Iinkcukacha zokucaciswa
imo	Utywala
Kubonakala	Ulwelo olucacileyo olucacileyo
Umxholo wePeptide	500ppm – 1000ppm (Ingenziwa ngokwezifiso)
Imiqathango yoGcino	Ingathuthwa kubushushu begumbi. Gcina kwindawo eyomileyo, emnyama kwi-2-8°C ukuze igcinwe ixesha elide.
Packaging	I-1Kg okanye i-5kg, okanye iipakeji ezenziwe ngokwezifiso ezisekelwe kwizicelo ezikhethekileyo.
uphando	[Cela iNgqikelelo / iiSampuli ze-odolo]

I-Hexapeptide-33 ithintela ii-melanin ezibangela ulusu ngokusebenzisa i-GPCR antagonism, ithintela i-tyrosinase, kwaye ithintela i-PIH ukuze ulusu lukhanye ngononophelo oluphezulu.

Inzuzo kunye neNzuzo

uphawu	iinkcukacha
Ukunqumla koMqondiso	Isebenza njengomchasi we-GPCR ukuvimba i-α-MSH, uphawu oluphambili "lokuqala" lwemveliso ye-melanin.
Tyrosinase Inhibition	Inciphisa ngokuthe ngqo umsebenzi we-tyrosinase ukuthintela ukuguqulwa kwe-DOPA ibe yi-melanin.
Uthintelo lwe-PIH	Isebenza kakhulu ekuthomalaliseni iimpawu zoxinzelelo ezikhokelela kwi-hyperpigmentation emva kokudumba.
Ukuqaqambisa ngokuchanekileyo	Ijolise kwiindawo ezimnyama kunye nebala lolusu elingalinganiyo ngononophelo lotyando kwinqanaba leemolekyuli.
Inkangeleko yoKhuseleko	Indlela yokwenza mhlophe ngaphandle kokusebenzisa i-cytotoxic ekhanyisa ulusu ngaphandle kokonakalisa impilo ye-melanocyte.

FAQs

Umbuzo 1: Yeyiphi indlela iHexapeptide-33 (SFKLRY-NH₂) enika ngayo iingenelo zokulwa nombala wolusu lobuso, kwaye bubuphi ubungqina be-in vitro obuxhasa oku?

I-A :Hexapeptide-33 (ulandelelwano lwe-Ser-Phe-Lys-Leu-Arg-Tyr-NH₂) ithintela ukwenziwa kwe-melanin ngeendlela ezimbini ezihambelanayo. Isebenza njenge-inhibitor ye-tyrosinase ethe ngqo, inciphisa ukwakheka kwe-melanin kwiiseli ze-melanoma ze-B16. Ukongeza, isebenza njenge-endothelin-1 receptor antagonist, ivimba i-ET-1 signaling evuselela i-melanogenesis. Kwi-vitro, inciphisa ukuveliswa kwe-melanin ngaphezulu kwe-40% kwaye inciphisa amanqanaba eprotheyini ye-tyrosinase kwiiseli ze-B16. Uphononongo luka-2009 (uLee et al., Int J Pept Res Ther 15:281–286) luqale lwaxela ezi mpawu zokulwa ne-melanogenic kunye ne-antioxidant zale peptide.

Umbuzo 2: I-Hexapeptide-33 iyithintela njani i-melanin ngaphandle kobukrakra bee-asidi zemveli?

A: Ngokungafaniyo ne-AHAs okanye iVithamini C enokucaphukisa, iHexapeptide-33 yiBiomimetic Signal Blocker . Ijolise kwi -GPCRs (ii-G-Protein-Coupled Receptors) kwi-melanocytes ukuze iphazamise "umyalelo we-tanning." Ngokuthintela i-signaling cascade ekhokelela kwi-melanin synthesis, ifumana isiphumo esinamandla sokukhanyisa ngelixa ihlala ithomalalisa kwaye ikhuselekile kulusu olubuthathaka.

Umbuzo 3: Ngaba ijolise kwi-Post-Inflammatory Hyperpigmentation (PIH)?

A: Kulapho iHexapeptide-33 ikhanya khona ngokwenene. Ngenxa yelifa layo "lokulungisa amanxeba" , isebenza kakuhle ekuthinteleni nasekunyamalaleni kwe-PIH (amabala amnyama ashiywe yi-acne okanye iinkqubo). Ithomalalisa imiqondiso yokuvuvukala edla ngokubangela ukuba i-melanocytes ivelise umbala ogqithisileyo, iqinisekisa ukuba ulusu olulungisiweyo luyaphola ngethoni ecacileyo nelinganayo.

Umbuzo 4: Ngaba iHexapeptide-33 ingalungisa amabala amnyama akhoyo kunye nebala lolusu elingalinganiyo?

A: Ewe. Ngokuhlala uthintela ukuveliswa kwe-melanin entsha kunye nokukhuthaza ukuguquka kwe-keratinocyte enempilo, ithintela amabala akhoyo ekubeni mnyama ngelixa ivumela ulusu ukuba lukhuphe iiseli ezinombala ngokwemvelo. Oku kukhokelela kwisiphumo esibonakalayo "sokukhanya kwehlabathi" kunye nobuso obukhanyayo nobufanayo.

Umbuzo 5: Ingaba iyahambelana nezinye izinto zokwenza mhlophe ezifana neNiacinamide okanye iTranexamic Acid?

A: Liqabane elifanelekileyo lokusebenzisana . Ngelixa iNiacinamide ivimba ukudluliselwa kwe -melanin kwaye iTranexamic Acid ijolise kwi -plasmin , iHexapeptide-33 isebenza kwinqanaba lokuqala lokubonisa . Ukuzidibanisa kudala ukhuselo olunemigangatho emininzi ngokuchasene nokunyuka kwebala, olugubungela inyathelo ngalinye ukusuka "kwisignali" ukuya "kwibala".

Umbuzo 6: Kutheni kucetyiswa ukuba kwenziwe mhlophe "Ngemva kweLaser" okanye "Ngemva kweLaser"?

A: Ukuvezwa yi-UV kunye nonyango lwe-laser kubangela ukukhululwa okukhulu kwe-α-MSH (i-melanocyte-stimulating hormone). I-Hexapeptide-33 ingena njengekhaka le-molecular, inciphisa imiqondiso yoxinzelelo ebangela "ukubuyela umva" kombala. Yinto efanelekileyo yokuqinisekisa ukuba ulusu luhlala lukhanya emva kokuba lujamelene noxinzelelo lwangaphandle.