Professional Cosmetics Peptide Supplier | GENOPEP
Cosmetic Peptide
Dipeptide-4（CAS:19246-18-5） Brightening Peptides
Dipeptide-4（CAS:19246-18-5） Anti-pigmentation Peptides
Dipeptide-4（CAS:19246-18-5） Anti-Aging Peptides
Acetyl Decapeptide-3 (CAS：935288‑50‑9) Brightening Peptide
Acetyl Decapeptide-3 (CAS：935288‑50‑9) Anti-pigmentation Peptide
Acetyl Decapeptide-3 (CAS：935288‑50‑9) Sensitive Skin Care Peptide
GENOPEP — Professional Cosmetic Peptide Supplier & Innovation Partner
Cosmetic peptides represent the vanguard of biocellular intervention in modern skincare. Far beyond inert excipients, these biosynthetic signaling molecules are engineered to cross the stratum corneum and engage specific cellular receptors — acting as "molecular keys" that restore the skin's dynamic ecosystem at the source, rather than merely conditioning its surface.
GENOPEP develops and manufactures a comprehensive portfolio of high-purity cosmetic peptides — including signal peptides, carrier peptides, and neurotransmitter peptides — for global skincare brands, cosmetic formulators, and ingredient distributors. Every ingredient is supported by analytical validation (HPLC purity assessment) and, where applicable, clinical substantiation, so your claims rest on evidence rather than assertion.
The Science: Why Peptides Are the Active Intelligence of Skincare
Classification — Signal, Carrier, and Neurotransmitter Peptides
Cosmetic peptides are functionally classified by the biological role they play within the formulation:
- Signal peptides (e.g., Palmitoyl Pentapeptide-4, Palmitoyl Tripeptide-5) mimic endogenous ligands to stimulate fibroblasts and upregulate collagen, elastin, and glycosaminoglycans.
- Carrier peptides (e.g., Copper Tripeptide-1) deliver essential trace metals to enzymes that drive tissue repair and remodeling.
- Neurotransmitter peptides (e.g., Acetyl Hexapeptide-8, Acetyl Octapeptide-3) moderate the SNARE complex to soften the appearance of expression lines.
Mechanism — Engaging the Dermal Ecosystem
Intrinsic aging and extrinsic stressors (ultraviolet radiation, pollution) progressively impair signaling pathways and degrade the Extracellular Matrix (ECM) — the decline of Type I/III collagen, elastin, and glycosaminoglycans. Peptides intervene by:
- Stimulating fibroblasts to upregulate collagen and fibronectin synthesis
- Modulating inflammatory cascades (e.g., IL-6, cathelicidin pathways)
- Supporting dermo-epidermal junction (DEJ) integrity and barrier cohesion
Delivery & Stability — Protecting Potent Molecules
A bioactive's efficacy is governed by its molecular weight, lipophilicity, and stability. GENOPEP supports formulation success with advanced delivery systems — liposomal encapsulation and micellar technology — that shield sensitive peptides from premature oxidation and enhance transdermal reach. Ingredient selection is increasingly guided by "Omics" technologies (genomics, proteomics, metabolomics) for targeted, evidence-based formulation.
Explore the Cosmetic Peptide Portfolio
GENOPEP's peptide library is organized by skin application and concern, helping formulators match the right molecule to the right product concept. For every ingredient we provide INCI name, CAS number, molecular target, and mechanism of action.
Facial Care — Anti-Wrinkle & Expression Line Peptides
Advanced peptides for visible wrinkle care, firmness, and expression-line smoothing.
| INCI Name | CAS No. | Target | Mechanism |
| Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn-Ake) | 823202-99-9 | nAChR | Antagonist of muscle nicotinic ACh receptor |
| Acetyl Octapeptide-3 | 868844-74-0 | SNAP-25 | Enhanced SNARE complex inhibition |
| Acetyl Hexapeptide-8 | 616204-22-9 | SNAP-25 | SNARE complex destabilizer |
| S-Mu-Conotoxin Cniiic | 936616-33-0 | muscle nAChR/Nav1.4 | Selective Nav1.4 inhibition & neuromuscular blockade |
| Acetyl Decapeptide-3 | 935288-50-9 | FGF receptor | Mimics FGF to stimulate cell growth |
| Acetyl Dipeptide-1 | 196604-48-5 | μ-opioid receptor | Inhibiting CGRP and pro-inflammatory release |
| Heptapeptide-7 | — | Keratinocytes | Promotes skin regeneration |
| Hexapeptide-3 | 1205679-02-2 | PGC-1alpha | Stimulates adipogenesis; volume boost |
| Hexapeptide-9 | 1228371-11-6 | Collagen IV/VII | Promotes DEJ repair |
| Hexapeptide-10 | 146439-94-3 | Laminin V | Boosts Laminin V and integrin expression |
| Hexapeptide-33 | 1192135-40-2 | Laminin | Stimulating type I collagen & cell migration |
| Palmitoyl Hexapeptide-14 | 891498-01-4 | MMPs | MMP inhibition & extracellular matrix reconstruction |
| Palmitoyl Pentapeptide-4 | 214047-00-4 | Fibroblasts | Stimulates Collagen I, III, IV and Fibronectin |
| Palmitoyl Tripeptide-5 | 623172-56-5 | TGF-beta | Mimics TSP-1 to activate TGF-beta |
| Acetyl Tetrapeptide-22 | 1295648-76-8 | HSP70 | Boosts HSP70; thermostress protection |
| Palmitoyl Dipeptide-13 | — | Keratinocyte & B cell | Immunomodulation and desmosomal protein activation |
| Hexapeptide-2 | 87616-84-0 | ECM | Fibroblast activation & matrix synthesis |
| Hexapeptide-11 | 161258-30-6 | Proteasome | Modulates proteostasis; firming |
| Palmitoyl Hexapeptide-12 | 171263-26-6 | Fibroblasts | Elastin fragment stimulates chemotaxis |
| Palmitoyl Tripeptide-1 | 147732-56-7 | Fibroblasts | Stimulates Collagen and GAGs |
| Pentapeptide-18 | 64963-01-5 | Enkephalin receptor | Mimics enkephalins; hyperpolarizes neurons |
| Acetyl Tetrapeptide-3 | 827306-97-8 | ECM | Stimulating ECM protein synthesis |
| Tetrapeptide-4 | 960608-16-6 | cathelicidin | Inhibits cathelicidin induced inflammation |
Facial Care — Anti-Aging & Skin Firming Peptides
Peptides supporting collagen, elasticity, and structural rejuvenation for premium anti-aging concepts.
| INCI Name | CAS No. | Target | Mechanism |
| Acetyl Decapeptide-3 | 935288-50-9 | FGF receptor | Mimics FGF to stimulate cell growth |
| Acetyl Tetrapeptide-11 | 928006-88-6 | Syndecan-1 | Stimulates Syndecan-1 synthesis |
| Acetyl Tetrapeptide-2 | 757942-88-4 | Thymic factors | Immune boost; firming |
| Acetyl Tetrapeptide-9 | 928006-50-2 | Lumican | Stimulates lumican and collagen I |
| Acetyl Dipeptide-1 Cetyl Ester | 196604-48-5 | μ-opioid | Neurotransmitter modulation & muscle relaxation |
| Copper Tripeptide-1 | 49557-75-7 | Dermal Papilla | Enhances follicle vitality; repair |
| Carnosine | 305-84-0 | Free Radicals | Anti-glycation, antioxidant |
| Acetyl Hydroxyproline | 39966-33-7 | Fibroblasts/MMPs | Hydroxyproline precursor & MMP-1 inhibition |
| Acetyl Tetrapeptide-22 | 1295648-76-8 | HSP70 | Boosts HSP70; thermostress protection |
| Hexapeptide-33 | 1192135-40-2 | Laminin-5 | Promotes cell migration & Collagen I |
| Palmitoyl Pentapeptide-4 | 214047-00-4 | Fibroblasts | Stimulates Collagen I, III, IV and Fibronectin |
| Dipeptide-4 | 19246-18-5 | Skin Matrix | Supports amino acid pool for tissue repair |
| Dipeptide-13 | 38101-59-6 | Keratinocytes / Desmosomes | Upregulates barrier desmosome proteins for cell-cohesion repair |
| Hexapeptide-11 | 161258-30-6 | Proteasome | Modulates proteostasis; firming |
| Palmitoyl Hexapeptide-12 | 171263-26-6 | Fibroblasts | Elastin fragment stimulates chemotaxis |
| Myristoyl Tripeptide-31 | 1453120-00-7 | Retinoic acid pathway | Retinol-like activity without irritation |
| Pentapeptide-1 | 69558-55-0 | Enkephalin receptor | Mimics enkephalins; hyperpolarizes neurons |
| Tetrapeptide-4 | 960608-16-6 | cathelicidin | Inhibits cathelicidin induced inflammation |
| Acetyl Tetrapeptide-3 | 827306-97-8 | ECM | Stimulating ECM protein synthesis |
| Palmitoyl Hexapeptide-14 | 891498-01-4 | MMPs | Stimulates extracellular matrix reconstruction |
| Palmitoyl Tripeptide-5 | 623172-56-5 | TGF-beta | Mimics TSP-1 to activate TGF-beta |
| Decarboxy Carnosine HCl | 57022-38-5 | Free Radicals | Anti-glycation, antioxidant |
| Acetyl Dipeptide-13 Diphenylglycine | 1334583-93-5 | Elastase | Competitive inhibition of cathepsins |
| Dipeptide-4 (L-Phe-L-Trp) | 24587-41-5 | SOD | Anti-glycation & anti-carbonylation defense |
| Palmitoyl Tripeptide-1 | 147732-56-7 | Fibroblasts | Stimulates Collagen and GAGs |
| Heptapeptide-7 | — | Keratinocytes | Promotes skin regeneration |
| Hexapeptide-2 | 87616-84-0 | Dermal Fibroblasts | Signaling dermal fibroblasts |
| Hexapeptide-3 | 1205679-02-2 | PGC-1alpha | Stimulates adipogenesis; volume boost |
| Hexapeptide-9 | 1228371-11-6 | Collagen IV/VII | Promotes DEJ repair |
| Hexapeptide-10 | 146439-94-3 | Laminin V | Boosts Laminin V and integrin expression |
Facial Care — Skin Repair & Barrier Support Peptides
Functional peptides for barrier-focused skincare, recovery products, and sensitive-skin formulations.
| INCI Name | CAS No. | Target | Mechanism |
| Copper Tripeptide-1 | 49557-75-7 | Dermal Papilla | Enhances follicle vitality; repair |
| Hexapeptide-33 | 1192135-40-2 | Laminin-5 | Stimulating type I collagen synthesis |
| Acetyl Decapeptide-3 | 935288-50-9 | FGF receptor | Mimics FGF to stimulate cell growth |
| Heptapeptide-7 | — | Keratinocytes | Promotes skin regeneration |
| Acetyl Tetrapeptide-3 | 827306-97-8 | Dermo-Epidermal Junction | Repairing the dermo-epidermal junction |
| Palmitoyl Hexapeptide-12 | 171263-26-6 | Fibroblasts | Elastin fragment stimulates chemotaxis |
| Acetyl Dipeptide-13 Diphenylglycine | 1334583-93-5 | Elastase | Competitive inhibition of elastase |
Facial Care — Soothing & Anti-Inflammatory Peptides
Gentle peptides for sensitive, stressed, and discomfort-prone skin.
| INCI Name | CAS No. | Target | Mechanism |
| Acetyl Tetrapeptide-40 | 1472633-28-5 | cathelicidin | Inhibits cathelicidin induced inflammation |
| Palmitoyl Tetrapeptide-7 | 221227-05-0 | IL-6 | IL-6 inhibitor & matrix protection |
| Acetyl Tetrapeptide-15 | 928007-64-1 | mu-opioid receptor | Reduces TRPV1 response; neuro-soothing |
| Pentapeptide-59 | — | TRPV1 Receptor | Inhibits TRPV1 activation |
| Acetyl Decapeptide-3 | 935288-50-9 | FGF receptor | Mimics FGF to stimulate cell growth |
| Acetyl Tetrapeptide-3 | 827306-97-8 | ECM | Modulating inflammatory microenvironment |
| Pentapeptide-1 | 69558-55-0 | Enkephalin receptor | Mimics enkephalins; hyperpolarizes neurons |
| Decarboxy Carnosine HCl | 57022-38-5 | Free Radicals | Anti-glycation, antioxidant |
Sensitive Skin Care Peptides
Calming solutions for reactive and sensitized skin.
| INCI Name | CAS No. | Target | Mechanism |
| Acetyl Tetrapeptide-40 | 1472633-28-5 | cathelicidin | Inhibits cathelicidin induced inflammation |
| Acetyl Tetrapeptide-15 | 928007-64-1 | mu-opioid receptor | Reduces TRPV1 response; neuro-soothing |
| Acetyl Decapeptide-3 | 935288-50-9 | FGF receptor | Mimics FGF to stimulate cell growth |
| Pentapeptide-1 | 69558-55-0 | Enkephalin receptor | Mimics enkephalins; hyperpolarizes neurons |
| Decarboxy Carnosine HCl | 57022-38-5 | Free Radicals | Anti-glycation, antioxidant |
| Pentapeptide-59 | — | TRPV1 Receptor | Inhibits TRPV1 activation |
| Acetyl Tetrapeptide-3 | 827306-97-8 | ECM | Modulating inflammatory microenvironment |
Brightening & Skin Tone Management Peptides
Radiance and even-tone concepts through pigmentation-pathway regulation and antioxidant protection.
| INCI Name | CAS No. | Target | Mechanism |
| Nonapeptide-1 | 158563-45-2 | MC1-R | alpha-MSH antagonist; blocks Tyrosinase |
| Acetyl Hydroxyproline | 39966-33-7 | AGEs | Inhibiting AGEs formation |
| Carnosine | 305-84-0 | Free Radicals | Anti-glycation, antioxidant |
| Hexapeptide-33 | 1192135-40-2 | Melanocytes | Competitive blockade of melanogenesis pathways |
| Decarboxy Carnosine HCl | 57022-38-5 | Free Radicals | Anti-glycation, antioxidant |
| Hexapeptide-2 | 87616-84-0 | MC1-R | Competitively binds to MC1-R |
| Myristoyl Tripeptide-31 | 1453120-00-7 | Retinoic acid pathway | Retinol-like activity without irritation |
| Dipeptide-4 (L-Phe-L-Trp) | 24587-41-5 | SOD / Glutathione | ROS scavenger & pigmentation inhibitor |
| Dipeptide-4 | 19246-18-5 | Cross-talk | Source-level signaling blocker |
| Acetyl Decapeptide-3 | 935288-50-9 | FGF receptor | Mimics FGF to stimulate cell growth |
Tanning & Melanin Activation Peptides
UV-free tanning and skin-tone optimization via natural pigmentation pathways.
| INCI Name | CAS No. | Target | Mechanism |
| Palmitoyl Tetrapeptide-20 | — | MC1-R/Catalase | Biomimetic alpha-MSH Peptide Agonist |
| Acetyl Hexapeptide-1 | — | MC1-R/Tyrosinase | MITF Pathway & Tyrosinase Accelerator |
| Isopropyl Octapeptide-2 | — | Tanning Cascade | Upstream Pigmentation Cascade Activator |
| Acetyl Octapeptide-5 | — | MC1-R / ECM | Keratinocyte-Melanocyte Cross-talk Modulator |
Eye Care Peptides
Specialized solutions for eye-area fine lines, puffiness, and dark circles.
Expression-Line & Anti-Wrinkle
| INCI Name | CAS No. | Target | Mechanism |
| Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn-Ake) | 823202-99-9 | nAChR | Antagonist of muscle nicotinic ACh receptor |
| Acetyl Octapeptide-3 | 868844-74-0 | SNAP-25 | Enhanced SNARE complex inhibition |
| Acetyl Hexapeptide-8 | 616204-22-9 | SNAP-25 | SNARE complex destabilizer |
| S-Mu-Conotoxin Cniiic | 936616-33-0 | muscle nAChR/Nav1.4 | Selective Nav1.4 inhibition & neuromuscular blockade |
| Acetyl Decapeptide-3 | 935288-50-9 | FGF receptor | Mimics FGF to stimulate cell growth |
| Acetyl Dipeptide-1 | 196604-48-5 | μ-opioid receptor | Inhibiting CGRP and pro-inflammatory release |
| Palmitoyl Pentapeptide-4 | 214047-00-4 | Fibroblasts | Stimulates Collagen I, III, IV and Fibronectin |
| Palmitoyl Hexapeptide-14 | 891498-01-4 | MMPs | MMP inhibition & extracellular matrix reconstruction |
| Palmitoyl Tripeptide-5 | 623172-56-5 | TGF-beta | Mimics TSP-1 to activate TGF-beta |
| Palmitoyl Tripeptide-1 | 147732-56-7 | Fibroblasts | Stimulates Collagen and GAGs |
| Pentapeptide-18 | 64963-01-5 | Enkephalin receptor | Mimics enkephalins; hyperpolarizes neurons |
| Tetrapeptide-4 | 960608-16-6 | cathelicidin | Inhibits cathelicidin induced inflammation |
Eye Bags & Dark Circles
| INCI Name | CAS No. | Target | Mechanism |
| Acetyl Tetrapeptide-5 | 820959-17-9 | ACE | Inhibits ACE; reduces vascular permeability |
| Dipeptide-2 | 24587-37-9 | ACE | ACE inhibition; reduces edema |
Hair Care Peptides
Functional peptides for hair and lash care.
| INCI Name | CAS No. | Target | Mechanism |
| Myristoyl Dipeptide-13 | 1644362-37-7 | Hair Follicle Root Cells | Proliferation and differentiation of hair follicle root cells |
| Myristoyl Hexapeptide-16 | 959610-54-9 | Keratin genes | Stimulates keratin gene expression |
Body Care Peptides
Innovative peptide ingredients for body beauty applications.
Lip Plumping
| INCI Name | CAS No. | Target | Mechanism |
| Acetyl Hexapeptide-38 | 1400634-44-7 | PGC-1alpha | Stimulates adipogenesis; volume boost |
| Hexapeptide-3 | 1205679-02-2 | PGC-1alpha | Stimulates adipogenesis; volume boost |
Bust Enhancement
| INCI Name | CAS No. | Target | Mechanism |
| Acetyl Hexapeptide-38 | 1400634-44-7 | PGC-1alpha | Stimulates adipogenesis; volume boost |
| Acetyl Tetrapeptide-2 | 757942-88-4 | Thymic factors | Immune boost; firming |
How to Select the Right Peptide
- Define the biological target — collagen/ECM remodeling, neuro-relaxation of expression lines, pigmentation control, or barrier repair.
- Confirm identity & compliance — verify INCI name, CAS number, and regulatory status for your market.
- Validate in your vehicle — assess stability, pH compatibility, and color/odor with our technical dossiers.
- Request samples & COA — our technical team supports formulation trials and scale-up.
FAQ
1. What differentiates GENOPEP's cosmetic peptides from standard cosmetic additives? Unlike inert excipients used for texture or stabilization, our peptides are biosynthetic bioactive ingredients — the functional heart of a formulation. They engage specific cellular receptors (fibroblasts, MC1-R, the SNARE complex) to drive measurable biological responses.
2. How do peptides address skin aging at the molecular level? Aging degrades the ECM and impairs signaling pathways. Signal and carrier peptides act as molecular keys that upregulate Type I/III collagen, elastin, and GAGs, restoring dermal structure and homeostatic balance.
3. How does GENOPEP ensure peptide stability and purity? We apply advanced delivery systems (liposomal encapsulation, micellar technology) and rigorous analytical validation via HPLC for purity, with clinically substantiated claims where applicable.
4. Can GENOPEP support custom peptide development? Yes. Our custom synthesis services cover novel molecule design, synthesis, and reference-standard preparation — supporting brands from concept to market.
GENOPEP — Your Partner in Peptide Innovation
GENOPEP Group is a leading global peptide technology solutions provider, specializing in R&D, manufacturing, and commercialization across skin science and biopharmaceuticals. Supported by advanced scientific capabilities and a fully integrated supply chain, we deliver efficient, reliable innovation support to skincare brands worldwide.
We focus on three key service areas across the full product lifecycle:
- Active Ingredients & Formulation Development — high-efficacy ingredients, complexes, and complete formulation solutions.
- End-to-End Production Support — from lab-scale R&D and pilot optimization to commercial manufacturing.
- Custom Synthesis Services — design, synthesis, and preparation of peptide-based novel ingredients and reference standards.
We believe in technology-driven products and collaboration-driven value. GENOPEP is not just a supplier — we are your trusted innovation partner, co-creating the next generation of skincare solutions.
Request Samples & Quotation
Whether you are developing anti-aging serums, repair creams, eye-care products, or innovative skincare concepts, our peptide specialists can help identify the right ingredients and provide technical consultation.