Professional Cosmetics Peptide Supplier | GENOPEP
Acetyl Decapeptide-3（CAS: 935288-50-9）Barrier Repair Peptide
PRODUCT PARAMETERS
Description
Acetyl Decapeptide-3 Basic Information
| Field Name | Basic information |
| INCI Name | Acetyl Decapeptide-3 |
| CAS No. | 935288-50-9 |
| Synonyms | Acetyl Decapeptide-3;Acetyl decapeptide-3/ Decapeptide-4;L-Tyrosinamide, N-acetyl-L-tyrosyl-L-arginyl-L-seryl-L-arginyl-L-lysyl-L-tyrosyl-L-threonyl-L-seryl-L-tryptophyl- |
| Key Benefit | Barrier Repair/Anti-Winkle/Anti-Aging/Soothing and Anti-Inflammatory/Sensitive Skin Care/ Anti-pigmentation/ Brightening |
Acetyl Decapeptide-3 Powder Specification
| Field Name | Basic information |
| Form | Powder |
| Appearance | White to off-white powder |
| Purity (HPLC) | ≥ 95% or ≥ 98% |
| Storage Conditions | Store sealed, protected from light and moisture. Long-term storage at -20°C is recommended. |
| Packaging | Glass/plastic sample bottles,or customized packages based on special requests. |
| Shipping | Express air freight with moisture-proof protection. |
| Inquiry | Request a Quote / Order Samples |
Acetyl Decapeptide-3 Solution Specification
| Item | Specification Details |
| Form | Liquid |
| Appearance | Clear Transparent Liquid |
| Peptide Content | 1000ppm (Customizable upon request) |
| Storage Conditions | Can transport at room temperature. Store in a dry, dark place at 2-8°C for long term storage. |
| Packaging | 1Kg or 5kg, or customized packages based on special requests. |
| Shipping | Express air freight with moisture-proof protection. |
| Sample | Request a Quote / Order Samples |
Acetyl Decapeptide-3 is a stable bFGF-mimetic peptide that boosts collagen synthesis and cell renewal. It involved in skin development, wound healing, regeneration, reduces wrinkles, enhances skin firmness, and long-lasting anti-aging performance.
Advantage and Benefit
| Feature | Details |
| FGFR Activation | Acts as a high-affinity ligand for FGFR, initiating receptor activation on the cell membrane. |
| Dermal Fibroblast Activation | Wakes up dormant fibroblasts in the dermis through signal transduction, promoting the growth and proliferation of fibroblasts, endothelial cells, and keratinocytes. |
| Extracellular Matrix (ECM) Synthesis | Significantly upregulates Type I Collagen (firmness), Elastin (bounce), and Glycosaminoglycans (hydration), while also increasing fibronectin and laminin. |
| Dermal-Epidermal Junction (DEJ) Strengthening | Increases expression of Laminin-5 and Fibronectin, reinforcing the bond between skin layers for visible lifting and structural integrity. |
| Multi-Functional Benefits | Reduces fine lines and wrinkles, improves elasticity, makes skin firmer and suppler; also promotes hair growth, strengthens hair follicles, and supports new cell development. |
FAQs
Q1: Why choose Acetyl Decapeptide-3 over native bFGF proteins in formulations?
A: While native bFGF is highly effective, it is notoriously unstable, expensive, and sensitive to temperature and pH fluctuations. Acetyl Decapeptide-3, featuring the sequence YRSRKYTSWY, offers superior stability and prolonged bioactivity. It provides a cost-effective, easy-to-handle alternative that maintains its structural integrity and performance throughout the shelf life of the finished cosmetic product.
Q2: Is Acetyl Decapeptide-3 compatible with other active ingredients?
A: Yes. Acetyl Decapeptide-3 is highly compatible with common skincare actives like Hyaluronic Acid, other signal peptides (e.g., Palmitoyl Pentapeptide-4), and antioxidants. Due to its stable synthetic nature, it integrates seamlessly into O/W emulsions, serums, and toners. We recommend adding it during the final stage of formulation at temperatures below 40°C to ensure maximum efficacy.
Q3: How does Acetyl Decapeptide-3 restore skin density and firmness at the molecular level?
A: Acetyl Decapeptide-3 acts as a high-affinity ligand for the FGFR (Fibroblast Growth Factor Receptor) on the cell membrane. Upon binding, it triggers a signaling cascade that activates dormant dermal fibroblasts. These activated fibroblasts then significantly upregulate the production of Type I Collagen (for firmness), Elastin (for bounce), and Glycosaminoglycans (for hydration), while also increasing Laminin-5 and Fibronectin to strengthen the dermal-epidermal junction. This multi-targeted mechanism restores skin density, elasticity, and structural integrity.
Q4: How does Acetyl Decapeptide-3 strengthen the skin barrier and align with Shiseido’s research on barrier homeostasis?
Answer: Acetyl Decapeptide-3 increases filaggrin (Filaggrin) expression, a key epidermal protein that aggregates keratin filaments and maintains barrier integrity, lowering transepidermal water loss (TEWL) by 18%. This aligns with Shiseido’s patented methods for barrier recovery via TRPV4 activation and TRPV1 blockade on epidermal cells, as well as screening methods using epidermal serine racemase and D‑serine as barrier function indicators. By reinforcing filaggrin and supporting DEJ components (collagen VII, laminin‑5), the peptide improves moisture retention and resilience.
GENOPEP GROUP | The Engine of Your Peptide Innovation
GENOPEP Group is a leading global peptide technology solutions provider, specializing in R&D, manufacturing, and commercialization in the fields of skin science and biopharmaceuticals. Supported by advanced scientific capabilities and a fully integrated supply chain, we deliver efficient and reliable innovation support to skincare brands worldwide.
We focus on three key service areas, empowering partners throughout the entire product lifecycle from concept to market:
- Active Ingredients and Formulation Development – Grounded in cutting-edge research, we provide high-efficacy skincare ingredients, ingredient complexes, and complete formulation solutions.
- End-to-End Production Support – Covering the full journey from lab-scale R&D and pilot optimization to commercial manufacturing, ensuring consistent product quality and reliable supply.
- Custom Synthesis Services – With strong capabilities in novel molecule development, we specialize in the design, synthesis, and preparation of peptide-based novel ingredients and related reference standards.
We believe in technology-driven products and collaboration-driven value. GENOPEP is not just a supplier—we are your trusted innovation partner, dedicated to co-creating the next generation of skincare solutions with you.
