Hexapeptide-33 Basic Information

Field Name	Basic information
INCI Name	Hexapeptide-33
CAS No.	1192135-40-2
Synonyms	Hexapeptide-33; W3 peptide ; Ser-Phe-Lys-Leu-Arg-Tyr-NH2; SFKLRY
Key Benefits	Anti-Wrinkle/ Anti-Aging /Barrier Repair

Hexapeptide-33 Powder Specification

Field Name	Basic information
Form	Powder
Appearance	White to off-white powder
Purity (HPLC)	≥ 95%, or ≥ 98%
Storage Conditions	Store sealed, protected from light and moisture. Long-term storage at -20°C is recommended.
Packaging	Glass/plastic sample bottles, or customized packages based on special requests.
Shipping	Express air freight with moisture-proof protection.
Inquiry	[Request a Quote / Order Samples]

Hexapeptide-33 Solution Specification

Field Name	Basic information
Form	Liquid
Appearance	Clear Transparent Liquid
Peptide Content	1000 ppm, 500 ppm (Customizable upon request)
Storage Conditions	Can transport at room temperature. Store in a dry, dark place at 2-8°C for long term storage.
Packaging	1Kg or 5kg, or customized packages based on special requests.
Shipping	Express air freight with moisture-proof protection.
Sample	Request a Quote / Order Samples

Hexapeptide-33: GPCR signal peptide. Boosts angiogenesis, collagen & barrier. Reduces wrinkles & hyperpigmentation.

Advantage and Benefit

Feature	Details
Barrier & DEJ Repair	Activates GPCR signaling to strengthen epidermal barrier and dermal-epidermal junction, reducing puffiness and dark circles.
Anti-Wrinkle & Firming	Stimulates collagen I/III and elastin synthesis while regulating MMPs, improving firmness and reducing fine lines.
Melanogenesis Inhibition	Directly inhibits tyrosinase and antagonizes ET-1 receptor, cutting melanin production by >40% for comprehensive whitening.
Antioxidant & Angiogenesis	Scavenges ROS, boosts SOD activity, and promotes VEGF-driven microcirculation, protecting against photoaging and brightening skin.

FAQs

Q1: How does Hexapeptide-33 specifically target deep structural wrinkles?

A: Hexapeptide-33 is a high-affinity ligand for G-Protein-Coupled Receptors (GPCRs), the “command centers” of skin cells. By activating these receptors, it sends an intense signal to fibroblasts to ramp up Collagen I synthesis. This doesn’t just surface-level smooth the skin; it physically “re-fills” the dermal matrix, pushing out deep wrinkles from the inside out.

Q2: What makes it superior for “Structural Repair” compared to basic peptides?

A: While many peptides only signal for more protein, Hexapeptide-33 promotes cell migration and proliferative activity. This means it doesn’t just add collagen; it actively recruits and “awakens” cells to migrate to areas of damage or aging, ensuring that the skin’s architectural repair is both rapid and strategically organized.

Q3: How does Hexapeptide-33 transform a compromised skin barrier?

A: It acts as a Barrier Architect. By triggering GPCR signaling in keratinocytes, it upregulates the genes for Tight Junctions, Ceramides, and Filaggrin. This creates a dual-action repair: it seals the gaps between cells to prevent water loss (TEWL) and stimulates the production of Natural Moisturizing Factors (NMF) to restore resilience.

Q4: Can this peptide be used in “Medical-Grade” post-procedure recovery?

A: Yes, it is a flagship ingredient for regenerative medicine. Its “Wound-repair” pathway accelerates re-epithelialization, making it ideal for post-laser, post-microneedling, or post-peel recovery. It significantly reduces downtime by “re-booting” the skin’s natural healing cascade at a cellular level.

Q5: Why is Hexapeptide-33 considered a “Master Switch” for youthful skin?

 A: Because it targets GPCRs—receptors that control a vast array of biological functions. By flipping this “Master Switch,” Hexapeptide-33 delivers a Multi-Pathway Anti-Aging effect: it combines collagen production (firmness) with barrier fortification (smoothness), resulting in skin that is both structurally younger and biologically stronger.