Professional Cosmetics Peptide Supplier | GENOPEP
Pentapeptide-18 (CAS: 64963-01-5) Anti-Wrinkle Peptide
PRODUCT PARAMETERS
Description
Pentapeptide-18 Basic Information
| Field Name | Basic information |
| INCI Name | Pentapeptide-18 |
| CAS No. | 64963-01-5 |
| Synonyms | Leuphasyl® (trade name);(D-Ala²)-Leu‑Enkephalin;H-Tyr-D-Ala-Gly-Phe-Leu-OH;YDAGFL |
| Key Benefits | Anti-wrinkle |
Pentapeptide-18 Powder Specification
| Field Name | Basic information |
| Form | Powder |
| Appearance | White to off-white powder |
| Purity (HPLC) | ≥ 95%, or ≥ 98% |
| Storage Conditions | Store sealed, protected from light and moisture. Long-term storage at -20°C is recommended. |
| Packaging | Glass/plastic sample bottles, or customized packages based on special requests. |
| Shipping | Express air freight with moisture-proof protection. |
| Inquiry | [Request a Quote / Order Samples] |
Pentapeptide-18 Solution Specification
| Field Name | Basic information |
| Form | Liquid |
| Appearance | Clear Transparent Liquid |
| Peptide Content | 1000 ppm, 500 ppm (Customizable upon request) |
| Storage Conditions | Can transport at room temperature. Store in a dry, dark place at 2-8°C for long term storage. |
| Packaging | 1Kg or 5kg, or customized packages based on special requests. |
| Shipping | Express air freight with moisture-proof protection. |
| Sample | Request a Quote / Order Samples |
Pentapeptide-18 (Leuphasyl, CAS 64963-01-5): enkephalin-mimetic peptide. Reduces ACh release, relaxes muscles, smooths expression wrinkles. Synergizes with Argireline.
Advantage and Benefit
| Feature | Details |
| Enkephalin Receptor Activation | Binds to opioid receptors on facial nerve cells, activating inhibitory G proteins (Gi) and blocking calcium influx without affecting other cell types. |
| Acetylcholine Release Inhibition | Prevents SNARE‑mediated synaptic vesicle fusion, reducing neurotransmitter release and relaxing muscle contractions for smoother expression lines. |
| Extended Half‑Life via D‑Ala Substitution | The unnatural D‑alanine at position 2 confers resistance to aminopeptidase degradation, prolonging anti‑wrinkle efficacy compared to natural enkephalins. |
| Synergistic Potentiation with Argireline | Works complementarily with Acetyl Hexapeptide‑8 to block the SNARE complex and calcium channels, achieving greater wrinkle reduction than either peptide alone. |
FAQs
Question 1 : How does Pentapeptide-18 achieve its anti-wrinkle effect compared to Botulinum Toxin?
Answer: Pentapeptide-18 mimics enkephalin, binding to opioid receptors on facial nerve cells. This activates inhibitory G proteins (Gi), closing calcium channels and reducing acetylcholine release at the neuromuscular junction. Muscles relax, smoothing expression lines (crow‘s feet, forehead wrinkles). Unlike botulinum toxin (which causes temporary paralysis), Pentapeptide-18 gently “turns down” nerve excitability, preserving natural facial expressions. Clinical data: 11.64% wrinkle depth reduction in 28 days. (Sources: CI.GUIDE; MOL Changes)
Question 2 (Combination with Argireline): Can Pentapeptide-18 be combined with Acetyl Hexapeptide-8 (Argireline) for enhanced anti-wrinkle effects?
Answer: Yes. Pentapeptide-18 and Acetyl Hexapeptide-8 target complementary pathways in the SNARE complex and neuronal calcium channels. Pentapeptide-18 works via enkephalin receptor-mediated G protein activation; Argireline directly interferes with SNARE formation. Combined use shows potentiating (synergistic) effects, yielding more noticeable wrinkle reduction than either peptide alone.
Question 3 (Stability Enhancement): Why is the D‑Ala residue in Pentapeptide-18 important for formulation stability?
Answer: Natural enkephalins use glycine at position 2, which is rapidly degraded by skin aminopeptidases. Pentapeptide-18 replaces glycine with D‑alanine, a non‑natural stereoisomer. This single substitution confers high protease resistance, extending the peptide‘s half‑life in the skin from hours to days. The result: longer‑lasting anti‑wrinkle efficacy, lower required dosage (0.005%–0.05%), and stable activity in finished products. (Source: MOL Changes)
Question 4 (Formulation Parameters): What are the recommended dosage and formulation conditions for Pentapeptide-18?
Answer: Recommended usage: 0.005%–0.05% (50–500 ppm) in leave-on products. Pentapeptide-18 is water-soluble and stable at pH 4.0–7.5 (optimal pH 5.0–6.5). Add during the cooling phase below 40°C; avoid prolonged heating. Store raw material at -20°C, protected from light, desiccated. Shelf life: 24 months in original packaging. Synergistic partners: Acetyl Hexapeptide-8 (Argireline) and retinol (SLN co‑encapsulation enhances stability). (Sources: NIKOO Chemical; SciPeptide; Pawłowska et al., 2024)
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