Professional Cosmetics Peptide Supplier | GENOPEP
Palmitoyl Tripeptide-1（CAS: 147732‑56‑7） Anti-Wrinkle Peptide
PRODUCT PARAMETERS
Description
Palmitoyl Tripeptide-1 Basic Information
| Field Name | Basic information |
| INCI Name | Palmitoyl Tripeptide-1 |
| CAS No. | 147732‑56‑7 |
| Synonyms | Biopeptide CL™ (Sederma)；Pal-GHK；N-palmitoyl-glycyl-L-histidyl-L-lysine；Collaxyl II |
| Key Benefits | Anti-Wrinkle & Anti-Aging |
Palmitoyl Tripeptide-1 Powder Specification
| Field Name | Basic information |
| Form | Powder |
| Appearance | White to off-white powder |
| Purity (HPLC) | ≥ 95%, or ≥ 98% |
| Storage Conditions | Store sealed, protected from light and moisture. Long-term storage at -20°C is recommended. |
| Packaging | Glass/plastic sample bottles, or customized packages based on special requests. |
| Shipping | Express air freight with moisture-proof protection. |
| Inquiry | [Request a Quote / Order Samples] |
Palmitoyl Tripeptide-5 Solution Specification
| Field Name | Basic information |
| Form | Liquid |
| Appearance | Clear Transparent Liquid |
| Peptide Content | 1000 ppm, 500 ppm (Customizable upon request) |
| Storage Conditions | Can transport at room temperature. Store in a dry, dark place at 2-8°C for long term storage. |
| Packaging | 1Kg or 5kg, or customized packages based on special requests. |
| Shipping | Express air freight with moisture-proof protection. |
| Sample | Request a Quote / Order Samples |
Palmitoyl Tripeptide‑1: signal peptide activates TGF‑β, boosting collagen/GAGs, inhibiting MMPs, and reducing wrinkles.
Advantage and Benefit
| Feature | Details |
| TGF‑β Pathway Activation | Binds to fibroblast receptors and activates TGF‑β signaling, directly stimulating synthesis of collagen type I/III/IV, elastin, fibronectin and GAGs. |
| MMP Inhibition | Suppresses matrix metalloproteinase activity, protecting both existing and newly formed collagen fibers from enzymatic degradation. |
| Antioxidant Protection | Reduces reactive oxygen species (ROS) generation in fibroblasts in a concentration‑dependent manner, helping prevent oxidative damage. |
| Clinically Proven Anti‑Wrinkle | Double‑blind trial confirms reduced wrinkle depth, volume, density and deep wrinkle area, with improved skin roughness and tone. |
FAQs
Q1:Does Palmitoyl Tripeptide‑1 have clinical evidence for anti‑wrinkle efficacy?
A: Yes. A randomized double‑blind clinical study on 28 volunteers showed that a cream containing the peptide significantly reduced wrinkle depth, volume and density, improved skin roughness, and reduced deep wrinkle area. It also exhibits antioxidant activity by suppressing ROS in fibroblasts.
Q2:What is the primary mechanism by which Palmitoyl Tripeptide‑1 stimulates collagen synthesis in dermal fibroblasts?
A: It acts as a matrikine (signal peptide) mimicking a collagen‑I fragment. Binding to fibroblast receptors activates the TGF‑β pathway, which upregulates collagen type I/III/IV, elastin, fibronectin and glycosaminoglycan production, while also suppressing MMP activity to reduce ECM degradation.
Q3: Besides collagen stimulation, what additional extracellular matrix (ECM) components does Palmitoyl Tripeptide-1 target, and what clinical data support its anti-wrinkle efficacy?
A: Palmitoyl Tripeptide-1 remodels ECM by stimulating collagen (I, III, IV), fibronectin, elastin and GAGs (e.g., hyaluronic acid). It also inhibits MMPs, preserving both new and existing collagen fibers. A randomized double‑blind study (28 volunteers) showed reduced wrinkle depth, volume and density, improved roughness and decreased deep wrinkle area. Another 4‑week study reported 39% decrease in wrinkle length and 23% decrease in depth.
Q4: Does Palmitoyl Tripeptide-1 possess antioxidant activity in addition to its role as a signal peptide?
A: Yes. Palmitoyl Tripeptide-1 has antioxidant activity beyond signal peptide function. Using ESR spin‑trapping, Sakuma et al. (2018) showed it effectively reduces hydroxyl and peroxyl radicals. It also decreases ROS and inflammatory cytokines, enhances antioxidant enzyme activity, and suppresses NF‑κB and p38 MAPK pathways. Thus, it provides dual anti‑aging benefits: ECM stimulation plus oxidative protection.
GENOPEP GROUP | The Engine of Your Peptide Innovation
GENOPEP Group is a leading global peptide technology solutions provider, specializing in R&D, manufacturing, and commercialization in the fields of skin science and biopharmaceuticals. Supported by advanced scientific capabilities and a fully integrated supply chain, we deliver efficient and reliable innovation support to skincare brands worldwide.
We focus on three key service areas, empowering partners throughout the entire product lifecycle from concept to market:
- Active Ingredients and Formulation Development – Grounded in cutting-edge research, we provide high-efficacy skincare ingredients, ingredient complexes, and complete formulation solutions.
- End-to-End Production Support – Covering the full journey from lab-scale R&D and pilot optimization to commercial manufacturing, ensuring consistent product quality and reliable supply.
- Custom Synthesis Services – With strong capabilities in novel molecule development, we specialize in the design, synthesis, and preparation of peptide-based novel ingredients and related reference standards.
We believe in technology-driven products and collaboration-driven value. GENOPEP is not just a supplier—we are your trusted innovation partner, dedicated to co-creating the next generation of skincare solutions with you.
