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Acetyl Tetrapeptide-22 (CAS: 1295648-76-8) Anti-Aging Peptides
PRODUCT PARAMETERS
Acetyl Tetrapeptide-22
CAS: 1295648-76-8
Anti-Aging
Acetyl Tetrapeptide-22 boosts HSP70 levels to enhance cellular stress tolerance, aiding protein folding and repair for resilient, vital skin.
Description
Acetyl Tetrapeptide-22 Basic Information
| Field Name | Basic information |
| INCI Name | Acetyl Tetrapeptide-22 |
| CAS No. | 1295648-76-8 |
| Synonyms | Acety Tetrapeptide-22; Thermostressine; L-Arginine, N-acetyl-L-histidyl-L-leucyl-L-leucyl |
| Key Benefits | Anti-Aging |
Acetyl Tetrapeptide-22 Powder Specification
| Field Name | Basic information |
| Form | Powder |
| Appearance | White to off-white powder |
| Purity (HPLC) | ≥ 95%, or ≥ 98% |
| Storage Conditions | Store sealed, protected from light and moisture. Long-term storage at -20°C is recommended. |
| Packaging | Glass/plastic sample bottles, or customized packages based on special requests. |
| Shipping | Express air freight with moisture-proof protection. |
| Inquiry | [Request a Quote / Order Samples] |
Acetyl Tetrapeptide-22 Solution Specification
| Field Name | Specification Details |
| Form | Liquid |
| Appearance | Clear Transparent Liquid |
| Peptide Content | 500ppm – 1000ppm (Customizable) |
| Storage Conditions | Can transport at room temperature. Store in a dry, dark place at 2-8°C for long term storage. |
| Packaging | 1Kg or 5kg, or customized packages based on special requests. |
| Inquiry | [Request a Quote / Order Samples] |
Acetyl Tetrapeptide-22 boosts HSP70 levels to enhance cellular stress tolerance, aiding protein folding and repair for resilient, vital skin.

Advantage and Benefit
| Feature | Details |
| HSP70 Induction | Significantly increases Heat Shock Protein 70 to protect cells from thermal and oxidative stress. |
| Protein Chaperone | Prevents protein denaturing and promotes correct folding, maintaining the integrity of the ECM. |
| Environmental Shield | Enhances skin’s tolerance to extreme temperatures, UV, and urban pollutants. |
| Anti-Wrinkle Efficacy | Reduces the appearance of fine lines by maintaining functional protein levels in the dermis. |
FAQs
Q1: What is the biological role of “Heat Shock Proteins” like HSP70?
A: HSP70 acts as a “molecular chaperone.” Its job is to ensure that skin proteins (like collagen and enzymes) maintain their correct 3D shape. Under stress—such as UV exposure or temperature changes—proteins can denature or “unfold.” HSP70 repairs these proteins or prevents them from clumping, maintaining cellular health.
Q2: How does Acetyl Tetrapeptide-22 protect against “Thermal Stress”?
A: This peptide mimics the signals that trigger the skin’s natural stress response. By pre-emptively increasing HSP70 synthesis, it prepares the skin to handle sudden temperature fluctuations (hot or cold), reducing the cellular damage and inflammation typically caused by environmental “shocks.”
Q3: Is this peptide suitable for “Urban Shield” or “Anti-Pollution” products?
A: Absolutely. Modern “City-Shield” formulations benefit greatly from Acetyl Tetrapeptide-22 because it protects the skin from the oxidative and thermal stress caused by urban environments, infrared radiation, and even the blue light from screens that can contribute to “digital aging.”
GENOPEP GROUP | The Engine of Your Peptide Innovation
GENOPEP Group is a leading global peptide technology solutions provider, specializing in R&D, manufacturing, and commercialization in the fields of skin science and biopharmaceuticals. Supported by advanced scientific capabilities and a fully integrated supply chain, we deliver efficient and reliable innovation support to skincare brands worldwide.
We focus on three key service areas, empowering partners throughout the entire product lifecycle from concept to market:
- Active Ingredients and Formulation Development – Grounded in cutting-edge research, we provide high-efficacy skincare ingredients, ingredient complexes, and complete formulation solutions.
- End-to-End Production Support – Covering the full journey from lab-scale R&D and pilot optimization to commercial manufacturing, ensuring consistent product quality and reliable supply.
- Custom Synthesis Services – With strong capabilities in novel molecule development, we specialize in the design, synthesis, and preparation of peptide-based novel ingredients and related reference standards.
We believe in technology-driven products and collaboration-driven value. GENOPEP is not just a supplier—we are your trusted innovation partner, dedicated to co-creating the next generation of skincare solutions with you.













