Professional Cosmetics Peptide Supplier | GENOPEP
Tetrapeptide-3 (CAS: 827306-97-8) Anti-Wrinkle Peptide
PRODUCT PARAMETERS
Description
Tetrapeptide-3 Basic Information
| Field Name | Basic information |
| INCI Name | Tetrapeptide-3 |
| CAS No. | 827306-97-8 |
| Synonyms | NH2-KGHK-NH2;L-Lysinamide, L-lysylglycyl-L-histidyl-;(2S)-2,6-diamino-N-[2-[[(2S)-1-[[(2S)-1,6-diamino-1-oxohexan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-2-oxoethyl]hexanamide |
| Key Benefits | Anti-Wrinkle/Anti-Aging/ Barrier Repair/Soothing and Anti-Inflammatory/Sensitive Skin Care |
Tetrapeptide-3 Powder Specification
| Field Name | Basic information |
| Form | Powder |
| Appearance | White to off-white powder |
| Purity (HPLC) | ≥ 95%, or ≥ 98% |
| Storage Conditions | Store sealed, protected from light and moisture. Long-term storage at -20°C is recommended. |
| Packaging | Glass/plastic sample bottles, or customized packages based on special requests. |
| Shipping | Express air freight with moisture-proof protection. |
| Inquiry | [Request a Quote / Order Samples] |
Tetrapeptide-3 Solution Specification
| Field Name | Basic information |
| Form | Liquid |
| Appearance | Clear Transparent Liquid |
| Peptide Content | 1000 ppm, 500 ppm (Customizable upon request) |
| Storage Conditions | Can transport at room temperature. Store in a dry, dark place at 2-8°C for long term storage. |
| Packaging | 1Kg or 5kg, or customized packages based on special requests. |
| Shipping | Express air freight with moisture-proof protection. |
| Sample | Request a Quote / Order Samples |
Tetrapeptide-3: bioactive peptide (KGHK-NH₂, CAS 827306-97-8). Reduces IL-8 inflammation, stimulates ECM, repairs skin barrier. Anti-aging.
Advantage and Benefit
| Feature | Details |
| SPARC‑Derived Angiogenic Signaling | Mimics the endogenous KGHK peptide released from SPARC during vascular remodeling, stimulating angiogenesis and microvascular support for dermal health. |
| Pericyte‑Epidermal Axis Activation | Conceptually aligns with Shiseido‘s discovery that capillary‑associated pericytes migrate and transform into epidermal stem‑like cells, linking vascular integrity to epidermal renewal. |
| Triple Action: Anti‑Inflammation, ECM Remodeling, Barrier Repair | Suppresses IL‑8, stimulates type III collagen and laminins, and reinforces DEJ components (laminin‑5, collagen VII, fibronectin) to calm, firm, and protect skin. |
| Biomimetic Multitarget Rejuvenation | Bridges vascular biology, anti‑inflammation, ECM restoration, and barrier function into one peptide, offering a comprehensive approach to age‑related skin decline. |
FAQs
Q1: How does Tetrapeptide-3 reduce facial wrinkles through DEJ reinforcement?
A: Tetrapeptide-3 stimulates the production of laminin-5, fibronectin, and collagen VII—key structural proteins at the dermal-epidermal junction (DEJ). By strengthening the DEJ, it anchors the epidermis more firmly to the dermis, reduces fine lines and wrinkles, and improves overall skin firmness and resilience (source: Creative-Peptides; AusHealthIngredients).
Q2: What is the relationship between Tetrapeptide-3 and the matrix protein SPARC in skin regeneration?
A: Tetrapeptide-3 contains the bioactive sequence KGHK, which is naturally released from the extracellular matrix protein SPARC during vascular remodeling. This tetrapeptide stimulates angiogenesis, regulates endothelial cell proliferation, and promotes tissue repair. By mimicking this natural signaling pathway, Tetrapeptide-3 helps restore microvascular support and dermal-epidermal communication, contributing to overall skin regeneration and resilience (source: Lane et al., J Cell Biol, 1994, PMC2120067; GLPBIO).
Q3: How does Tetrapeptide-3 conceptually align with Shiseido‘s discovery on pericyte-driven epidermal renewal?
A: Shiseido discovered that pericytes from dermal capillaries can migrate to the epidermis and transform into epidermal stem-like cells, promoting regeneration. Aging increases epidermal-derived Netrin-1, repelling capillaries and reducing pericyte migration. Tetrapeptide-3’s KGHK sequence—derived from SPARC during vascular remodeling—supports angiogenesis and microvascular health, conceptually complementing this capillary–epidermis axis. Together, they suggest a unified strategy: maintaining capillary function and ECM signaling to sustain epidermal stem cell supply and skin renewal (source: Shiseido News Release, 2022; Lane et al., J Cell Biol, 1994).
GENOPEP GROUP | The Engine of Your Peptide Innovation
GENOPEP Group is a leading global peptide technology solutions provider, specializing in R&D, manufacturing, and commercialization in the fields of skin science and biopharmaceuticals. Supported by advanced scientific capabilities and a fully integrated supply chain, we deliver efficient and reliable innovation support to skincare brands worldwide.
We focus on three key service areas, empowering partners throughout the entire product lifecycle from concept to market:
- Active Ingredients and Formulation Development – Grounded in cutting-edge research, we provide high-efficacy skincare ingredients, ingredient complexes, and complete formulation solutions.
- End-to-End Production Support – Covering the full journey from lab-scale R&D and pilot optimization to commercial manufacturing, ensuring consistent product quality and reliable supply.
- Custom Synthesis Services – With strong capabilities in novel molecule development, we specialize in the design, synthesis, and preparation of peptide-based novel ingredients and related reference standards.
We believe in technology-driven products and collaboration-driven value. GENOPEP is not just a supplier—we are your trusted innovation partner, dedicated to co-creating the next generation of skincare solutions with you.
