DECARBOXY CARNOSINE HCL Basic Information

Field Name	Basic information
INCI Name	DECARBOXY CARNOSINE HCL
CAS No.	57022-38-5
Synonyms	Carcinine dihydrochloride;Alistin;β-Alanylhistamine dihydrochloride;3‑Amino‑N‑[2‑(1H‑imidazol‑4‑yl)ethyl]propanamide dihydrochloride;Decarboxy carnosine hydrochloride
Key Benefits	Anti-Aging/ Anti-pigmentation/ Brightening/ Soothing and Anti-Inflammatory/ Sensitive Skin Care

DECARBOXY CARNOSINE HCL Powder Specification

Field Name	Basic information
Form	Powder
Appearance	White to off-white powder
Purity (HPLC)	≥ 95%, or ≥ 98%
Storage Conditions	Store sealed, protected from light and moisture. Long-term storage at -20°C is recommended.
Packaging	Glass/plastic sample bottles, or customized packages based on special requests.
Shipping	Express air freight with moisture-proof protection.
Inquiry	[Request a Quote / Order Samples]

DECARBOXY CARNOSINE HCL Solution Specification

Field Name	Basic information
Form	Liquid
Appearance	Clear Transparent Liquid
Peptide Content	10000 ppm, 2000 ppm (Customizable upon request)
Storage Conditions	Can transport at room temperature. Store in a dry, dark place at 2-8°C for long term storage.
Packaging	1Kg or 5kg, or customized packages based on special requests.
Shipping	Express air freight with moisture-proof protection.
Sample	Request a Quote / Order Samples

Decarboxy Carnosine HCl: stable anti-glycation & antioxidant peptide. Reduces AGEs 40%, brightens skin, soothes inflammation, protects mitochondria.

Advantage and Benefit

Feature	Details
Enhanced Stability & Skin Penetration	Decarboxylation confers resistance to enzymatic degradation and cationic charge improves stratum corneum penetration, ensuring prolonged activity.
Dual-Target Anti-Glycation Protection	Scavenges free reducing sugars and releases collagen from Schiff base intermediates, reducing AGEs deposition by up to 40% (J Cosmet Dermatol, 2018).
Broad-Spectrum Antioxidant & Mitochondrial Protection	Neutralizes multiple ROS (hydroxyl radicals, singlet oxygen) with 2.3‑fold higher efficiency than carnosine, and protects mitochondrial function.
Anti-Inflammatory & Skin Brightening	Suppresses NF‑κB and pro-inflammatory cytokines (TNF‑α, IL‑8), soothes irritation, reduces AGE‑induced yellowing, and improves skin tone.

FAQs

Q1:What is the primary anti-aging mechanism of Decarboxy Carnosine HCl?

A: Decarboxy Carnosine HCl (INCI name, CAS 57022‑38‑5) functions as a potent carbonyl quencher, neutralizing reactive dicarbonyl species that drive protein cross‑linking and AGEs formation. It also protects mitochondria by reducing glycative/oxidative stress and suppresses NF‑κB pathway activation, which lowers pro‑inflammatory cytokines (IL‑6, TNF‑α). An 8‑week clinical trial using 1.5% Decarboxy Carnosine HCl showed a 21% improvement in skin elasticity, a 28% reduction in periocular wrinkles, and an 18% increase in hydration.

Q2:How does Decarboxy Carnosine HCl differ from standard Vitamin E?

A: Most antioxidants, like Vitamin E, are only effective before lipid peroxidation occurs. Decarboxy Carnosine is a “post-peroxidation” specialist; it can convert harmful hydroperoxides into non-toxic fatty alcohols, repairing cell membranes that have already been stressed.

Q3: What is “Collagen Cross-linking” and why is it bad?

A: Under oxidative stress, dermal fibers like collagen undergo a process called cross-linking (often associated with browning). This makes the fibers rigid and brittle, leading to a permanent loss of skin elasticity and the formation of deep wrinkles.

Q4: Why is its “High Stability” important for formulators?

A: Naturally occurring Carnosine is easily broken down by enzymes (carnosinase) in the skin. Decarboxy Carnosine is a synthetic pseudodipeptide engineered to resist this enzymatic hydrolysis, ensuring it stays active in the skin for much longer.

Q5: Can it help with “Sugar-related” aging (Glycation)?

A: Yes. It significantly reduces glycation and the formation of Advanced Glycation End-products (AGEs). This limits “carbonyl stress,” which is a major driver of photoaging and yellowing of the skin.