Professional Cosmetics Peptide Supplier | GENOPEP
Palmitoyl Pentapeptide-4 (CAS: 214047-00-4) Anti-Wrinkle Peptides
PRODUCT PARAMETERS
Description
Palmitoyl Pentapeptide-4 Basic information
| Field Name | Basic information |
| INCI Name | Palmitoyl Pentapeptide-4 |
| CAS No. | 214047-00-4 |
| Synonyms | Palmitoyl pentapeptide-3;Matrixyl;Palmitoyl pentapeptide trifluoroacetic acid; Palmitoyl-Lys-Thr-Thr-Lys-Ser-OH |
| Key Benefits | Anti-Wrinkle / Anti-Aging |
Palmitoyl Pentapeptide-4 Powder Specification
| Field Name | Basic information |
| Form | powder |
| Appearance | White or off-white powder |
| Purity (HPLC) | ≥ 95%, or ≥ 98% |
| Storage Conditions | Store sealed, protected from light and moisture. Long-term storage at -20°C is recommended. |
| Packaging | Glass/plastic sample bottles,or customized packages based on special requests. |
| Shipping | Express air freight with moisture-proof protection. |
| Request a Quote / Order Samples | |
Palmitoyl Pentapeptide-4 Solution Specification
| Field Name | Basic information |
| Form | Liquid |
| Appearance | Clear Transparent Liquid |
| Peptide Content | 100ppm,500ppm(Customizable upon request) |
| Storage Conditions | Can transport at room temperature. Store in a dry, dark place at 2-8°C for long term storage. |
| Packaging | 1Kg or 5kg, or customized packages based on special requests. |
| Shipping | Express air freight with moisture-proof protection. |
| Request a Quote / Order Samples | |
Palmitoyl Pentapeptide-4 is a stable signal peptide that boosts collagen synthesis and epidermal thickness for non-irritating wrinkle repair.
Advantage and Benefit
| Feature | Details |
| Collagen Stimulation | Activates neosynthesis of extracellular matrix macromolecules like collagen, providing anti-wrinkle effect. |
| Anti-GAG & Epidermal Thickening | Inhibits excess production of aging-associated dermal glycosaminoglycans and induces epidermal thickening. |
| Non-Irritating Efficacy | Improves facial wrinkles without the skin redness or barrier damage caused by retinol and other actives. |
| Multi-Benefit Improvement | Reduces wrinkles, age spots, dark circles, and improves skin firmness based on subject self-assessments. |
FAQs
Q1: Why is Palmitoyl Pentapeptide-4 classified as a “Matrikine”?
A: Matrikines are messenger peptides capable of regulating cell activities through specific receptor interactions. Pal-KTTKS mimics a naturally occurring fragment of skin pro-collagen I. It acts as a signal to fibroblasts, triggering them to initiate the neosynthesis of extracellular matrix (ECM) macromolecules like collagen.
Q2: What is the functional purpose of the Palmitic Acid chain conjugation?
A: The original pentapeptide sequence (KTTKS) is ionic and hydrophilic, making penetration through lipid skin structures difficult. Conjugating it with a 16-carbon aliphatic palmitoyl chain significantly enhances its lipophilicity and stability, ensuring effective delivery into the dermis.
Q3: How does its anti-aging mechanism differ from Retinol?
A: While retinol accelerates cell turnover which can cause irritation, Pal-KTTKS works via Matrikine signaling to activate matrix renewal. It is proven to improve wrinkles clinically without the redness or barrier damage associated with retinoids, making it a superior alternative for sensitive skin.
Q4: Besides collagen, what other structural components does it regulate?
A: Data indicates it induces epidermal thickening and inhibits the excess production of dermal glycosaminoglycans (GAGs) associated with aging skin, contributing to improved skin firmness and resilience.
Q5: What specific clinical benefits have been observed in human testing?
A: Multiple chronic human tests confirm significant improvements in the appearance of facial wrinkles. Subject self-assessments also report significant improvements in skin firmness, age spots, and dark circles.
GENOPEP GROUP | The Engine of Your Peptide Innovation
GENOPEP Group is a leading global peptide technology solutions provider, specializing in R&D, manufacturing, and commercialization in the fields of skin science and biopharmaceuticals. Supported by advanced scientific capabilities and a fully integrated supply chain, we deliver efficient and reliable innovation support to skincare brands worldwide.
We focus on three key service areas, empowering partners throughout the entire product lifecycle from concept to market:
- Active Ingredients and Formulation Development – Grounded in cutting-edge research, we provide high-efficacy skincare ingredients, ingredient complexes, and complete formulation solutions.
- End-to-End Production Support – Covering the full journey from lab-scale R&D and pilot optimization to commercial manufacturing, ensuring consistent product quality and reliable supply.
- Custom Synthesis Services – With strong capabilities in novel molecule development, we specialize in the design, synthesis, and preparation of peptide-based novel ingredients and related reference standards.
We believe in technology-driven products and collaboration-driven value. GENOPEP is not just a supplier—we are your trusted innovation partner, dedicated to co-creating the next generation of skincare solutions with you.
