Professional Cosmetics Peptide Supplier | GENOPEP
Hexapeptide-10（CAS:146439-94-3） Anti-Wrinkle Peptide
PRODUCT PARAMETERS
Description
Hexapeptide-10 Basic Information
| Field Name | Basic information |
| INCI Name | Hexapeptide-10 |
| CAS No. | 146439-94-3 |
| Synonyms | Serilesine;SIKVAV;H-SER-ILE-LYS-VAL-ALA-VAL-OH;Hexapeptide-10;Serilesine;L-Seryl-L-isoleucyl-L-lysyl-L-valyl-L-alanyl-L-valine;L-Valine |
| Key Benefits | Anti-Wrinkle Anti-Aging |
Hexapeptide-10 Powder Specification
| Field Name | Basic information |
| Form | Powder |
| Appearance | White to off-white powder |
| Purity (HPLC) | ≥ 95%, or ≥ 98% |
| Storage Conditions | Store sealed, protected from light and moisture. Long-term storage at -20°C is recommended. |
| Packaging | Glass/plastic sample bottles, or customized packages based on special requests. |
| Shipping | Express air freight with moisture-proof protection. |
| Inquiry | [Request a Quote / Order Samples] |
Hexapeptide-10 Solution Specification
| Field Name | Basic information |
| Form | Liquid |
| Appearance | Clear Transparent Liquid |
| Peptide Content | 1000 ppm, 500 ppm (Customizable upon request) |
| Storage Conditions | Can transport at room temperature. Store in a dry, dark place at 2-8°C for long term storage. |
| Packaging | 1Kg or 5kg, or customized packages based on special requests. |
| Shipping | Express air freight with moisture-proof protection. |
| Sample | Request a Quote / Order Samples |
Hexapeptide-10: laminin mimetic. Boosts hemidesmosomes, increases keratinocytes 38% & fibroblasts 75%. Remodels DEJ for firm, vibrant skin.
Advantage and Benefit
| Feature | Details |
| Hemidesmosome Regeneration | Promotes α6-integrin and laminin-5 to create strong anchor points between keratinocytes and basement membrane, reversing DEJ flattening. |
| Growth Factor Cascade | Upregulates EGF, bFGF, TGF-β1 and VEGF, increasing keratinocyte proliferation by 38% and fibroblasts by 75% to re-densify skin. |
| Matrix Remodeling | Modulates MMP-2/MMP-9 to facilitate healthy tissue remodeling, improving dermal-epidermal structure and firmness. |
| Angiogenesis Support | Promotes localized angiogenesis to enhance nutrient exchange between dermis and epidermis, resulting in compact, vibrant skin architecture. |
FAQs
Q1: What makes Hexapeptide-10 a “Double-Action” restructurer?
A: Unlike many peptides that only focus on the dermis, Hexapeptide-10 works on both layers. It boosts keratinocyte proliferation by 38% and fibroblast proliferation by 75%. This dual action ensures that the skin is replenished with new cells while the underlying support structure is simultaneously rebuilt.
Q2: How does it restore the “Anchoring Ability” of aging skin?
A: Aging causes a loss of Hemidesmosomes—the protein “rivets” that anchor cells to the basement membrane. Hexapeptide-10 stimulates the synthesis of Laminin-5 and $\alpha6$-integrin, effectively regenerating these anchor points. This restores the dermo-epidermal junction (DEJ) and prevents the skin layers from sliding apart, which manifests as sagging.
Q3: Can Hexapeptide-10 influence cellular communication via growth factors?
A: Yes. It triggers a signaling cascade that increases the secretion of vital growth factors, including EGF (Epidermal Growth Factor), bFGF, and VEGF. This enhances cell migration and wound healing, making it an ideal active for post-procedure recovery and intense skin rejuvenation.
Q4: What role do MMP-2 and MMP-9 play in its mechanism?
A: While MMPs are often associated with degradation, Hexapeptide-10 uses them strategically for tissue remodeling. By modulating MMP-2 and MMP-9, it helps “clean up” disorganized matrix components, allowing for a more orderly and compact regeneration of the basal lamina.
Q5: Why is its concentration typically capped at 0.005%?
A: Because of its high purity and potent signaling capability, 0.005% is the optimal concentration to achieve a significant redensifying effect. At this level, it safely promotes healthy microcirculation (angiogenesis) and structural reinforcement without over-stimulating the tissue.
GENOPEP GROUP | The Engine of Your Peptide Innovation
GENOPEP Group is a leading global peptide technology solutions provider, specializing in R&D, manufacturing, and commercialization in the fields of skin science and biopharmaceuticals. Supported by advanced scientific capabilities and a fully integrated supply chain, we deliver efficient and reliable innovation support to skincare brands worldwide.
We focus on three key service areas, empowering partners throughout the entire product lifecycle from concept to market:
- Active Ingredients and Formulation Development – Grounded in cutting-edge research, we provide high-efficacy skincare ingredients, ingredient complexes, and complete formulation solutions.
- End-to-End Production Support – Covering the full journey from lab-scale R&D and pilot optimization to commercial manufacturing, ensuring consistent product quality and reliable supply.
- Custom Synthesis Services – With strong capabilities in novel molecule development, we specialize in the design, synthesis, and preparation of peptide-based novel ingredients and related reference standards.
We believe in technology-driven products and collaboration-driven value. GENOPEP is not just a supplier—we are your trusted innovation partner, dedicated to co-creating the next generation of skincare solutions with you.
