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Acetyl Tetrapeptide-11 (CAS: 928006-88-6) Anti-aging Peptides
PRODUCT PARAMETERS
Acetyl Tetrapeptide-11
CAS: 928006-88-6
Anti-Aging
Acetyl Tetrapeptide-11 boosts epidermal cohesion and strengthens skin structure, delivering a smoother, more youthful appearance.
Description
Acetyl Tetrapeptide-11 Basic Information
| Field Name | Basic information |
| INCI Name | Acetyl Tetrapeptide-11 |
| CAS No. | 928006-88-6 |
| Synonyms | 1-Acetyl-L-prolyl-L-prolyl-L-tyrosyl-L-leucine; acetyl tetrapeptide-11 Syniorage; Ac-PPYL-OH; Ac-PPYL |
| Key Benefits | Anti-aging |
Acetyl Tetrapeptide-11 Powder Specification
| Field Name | Specification Details |
| Form | Powder |
| Appearance | White to off-white powder |
| Purity (HPLC) | ≥ 95%, or ≥ 98% |
| Storage Conditions | Store sealed, protected from light and moisture. Long-term storage at -20°C is recommended. |
| Packaging | Glass/plastic sample bottles,or customized packages based on special requests. |
| Shipping | Express air freight with moisture-proof protection. |
| Inquiry | [Request a Quote / Order Samples] |
Acetyl Tetrapeptide-11 Solution Specification
| Field Name | Specification Details |
| Form | Liquid |
| Appearance | Clear Transparent Liquid |
| Peptide Content | 500ppm,1000ppm(Customizable upon request) |
| Storage Conditions | Can transport at room temperature. Store in a dry, dark place at 2-8°C for long term storage. |
| Packaging | 1Kg or 5kg, or customized packages based on special requests. |
| Shipping | Express air freight with moisture-proof protection. |
| Inquiry | [Request a Quote / Order Samples] |
Acetyl Tetrapeptide-11 boosts epidermal cohesion and strengthens skin structure, delivering a smoother, more youthful appearance.

Advantage and Benefit
| Feature | Details |
| Syndecan-1 Stimulation | Boosts production of Syndecan-1, a proteoglycan critical for epidermal cohesion, reversing age-related thinning and fragility. |
| Collagen XVII Upregulation | Increases Collagen XVII in hemidesmosomes, enhancing adhesion between the epidermis and the dermal-epidermal junction (DEJ). |
| Dual Cohesion & Adhesion | Strengthens both epidermal cell-to-cell cohesion and dermal-epidermal anchoring, improving overall skin architecture and resilience. |
| Visible Texture Refinement | Restores elasticity, firmness, and smoothness, delivering a more youthful, radiant complexion by rebuilding structural integrity. |
FAQs
Q1: How does Acetyl Tetrapeptide-11 address epidermal thinning?
A: As skin ages, the epidermis naturally thins and loses its structural integrity. This peptide specifically targets the two key molecules responsible for epidermal cohesion: Syndecan-1 (a proteoglycan) and Collagen XVII (a protein in hemidesmosomes). By boosting their production, it “thickens” the biological bond within the skin, making it less fragile and more youthful.
Q2: What is the benefit of targeting “Cohesion” and “Adhesion”?
A: Cohesion refers to how well the epidermal cells stick together, while adhesion refers to how firmly the epidermis is anchored to the dermis at the Dermal-Epidermal Junction (DEJ). By improving both, Acetyl Tetrapeptide-11 strengthens the skin’s overall architecture, which directly translates to improved elasticity, firmness, and a smoother surface.
Q3: How does Acetyl Tetrapeptide-11 differ from traditional anti-wrinkle peptides like matrixyl or argireline?
A: Traditional anti-wrinkle peptides often target collagen synthesis in the dermis (matrixyl) or muscle contraction (argireline). Acetyl Tetrapeptide-11 works uniquely at the epidermal level and the dermal-epidermal junction (DEJ). By boosting Syndecan-1 and Collagen XVII, it directly addresses age-related epidermal thinning and structural cohesion, making it an ideal complement to dermal-targeting peptides for comprehensive anti-aging.
Q4: Can Acetyl Tetrapeptide-11 be used in combination with other anti-aging actives, and what results can be expected over time?
A: Yes. Acetyl Tetrapeptide-11 is highly compatible with other peptides (e.g., Palmitoyl Tripeptide, Matrixyl), hyaluronic acid, and antioxidants. With regular twice-daily use, users typically notice improved skin firmness and reduced fragility within 4–6 weeks. Continued use over 2–3 months leads to visible refinement of skin texture, increased elasticity, and a more resilient, youthful appearance, particularly beneficial for mature or sensitive skin types.
GENOPEP GROUP | The Engine of Your Peptide Innovation
GENOPEP Group is a leading global peptide technology solutions provider, specializing in R&D, manufacturing, and commercialization in the fields of skin science and biopharmaceuticals. Supported by advanced scientific capabilities and a fully integrated supply chain, we deliver efficient and reliable innovation support to skincare brands worldwide.
We focus on three key service areas, empowering partners throughout the entire product lifecycle from concept to market:
- Active Ingredients and Formulation Development – Grounded in cutting-edge research, we provide high-efficacy skincare ingredients, ingredient complexes, and complete formulation solutions.
- End-to-End Production Support – Covering the full journey from lab-scale R&D and pilot optimization to commercial manufacturing, ensuring consistent product quality and reliable supply.
- Custom Synthesis Services – With strong capabilities in novel molecule development, we specialize in the design, synthesis, and preparation of peptide-based novel ingredients and related reference standards.
We believe in technology-driven products and collaboration-driven value. GENOPEP is not just a supplier—we are your trusted innovation partner, dedicated to co-creating the next generation of skincare solutions with you.













