Professional Cosmetics Peptide Supplier | GENOPEP
Pentapeptide-1 (CAS:69558-55-0) Anti-Aging Peptide
PRODUCT PARAMETERS
Description
Pentapeptide-1 Basic Information
| Field Name | Basic information |
| INCI Name | Pentapeptide-1 |
| CAS No. | 69558-55-0 |
| Synonyms | Thymopentin;Thymopoietin pentapeptide;TP-5; Arg-Lys-Asp-Val-Tyr (R-K-D-V-Y) |
| Key Benefits | Anti-Aging/ Soothing and Anti-Inflammatory/ Sensitive Skin Care |
Pentapeptide-1 Powder Specification
| Field Name | Basic information |
| Form | Powder |
| Appearance | White to off-white powder |
| Purity (HPLC) | ≥ 95%, or ≥ 98% |
| Storage Conditions | Store sealed, protected from light and moisture. Long-term storage at -20°C is recommended. |
| Packaging | Glass/plastic sample bottles, or customized packages based on special requests. |
| Shipping | Express air freight with moisture-proof protection. |
| Inquiry | [Request a Quote / Order Samples] |
Pentapeptide-1 Solution Specification
| Field Name | Basic information |
| Form | Liquid |
| Appearance | Clear Transparent Liquid |
| Peptide Content | 1000 ppm, 500 ppm (Customizable upon request) |
| Storage Conditions | Can transport at room temperature. Store in a dry, dark place at 2-8°C for long term storage. |
| Packaging | 1Kg or 5kg, or customized packages based on special requests. |
| Shipping | Express air freight with moisture-proof protection. |
| Sample | Request a Quote / Order Samples |
Pentapeptide-1 (Thymopentin, CAS 69558-55-0): immunomodulatory peptide. Reduces IL-8 & MMP-9, boosts collagen, enhances barrier. Anti‑inflammatory, anti‑aging.
Advantage and Benefit
| Feature | Details |
| IL‑8 Suppression | Decreases secretion of pro‑inflammatory cytokine IL‑8 in keratinocytes, effectively reducing redness, stinging, and irritation in sensitive and reactive skin. |
| Collagen & Elastin Synthesis | Stimulates dermal fibroblasts to produce collagen and elastin, improving skin thickness, firmness, and elasticity for anti‑aging benefits. |
| Skin Barrier Enhancement | Works synergistically with other oligopeptides to promote barrier‑related gene expression, strengthening the skin‘s defense against environmental stressors and microbes. |
| T‑Cell Modulation | Modulates helper T‑cell activity and reduces IL‑17 expression, helping regulate skin microflora and control chronic inflammation in conditions like psoriasis. |
FAQs
Q1:How does Pentapeptide-1 deliver anti-aging benefits for facial skin?
A: Pentapeptide-1 (sh-Pentapeptide-1, CAS 69558-55-0, sequence RKDVY) is a biomimetic signal peptide. As a fragment of the human hormone thymopoietin, it activates the skin‘s natural renewal processes. It works by stimulating dermal fibroblasts to synthesize type I/III collagen and elastin, which improves skin thickness, firmness, and elasticity. This targeted extracellular matrix remodeling reduces fine lines and wrinkles for a more youthful appearance. (Source: UL Prospector; CI.GUIDE)
Q2:How does Pentapeptide-1 promote collagen synthesis and support skin renewal?
A: Pentapeptide-1 is a biomimetic signal peptide derived from thymopoietin (sequence RKDVY). It activates dermal fibroblasts via the TGF-β pathway, upregulating the synthesis of type I/III collagen, fibronectin, and glycosaminoglycans, thereby improving skin thickness, firmness, and elasticity. By mimicking natural repair signals, it accelerates skin renewal and reduces the appearance of fine lines and wrinkles (Source: UL Prospector; CI.GUIDE).
Q3:What is the mechanism by which Pentapeptide-1 repairs the skin barrier and reduces inflammation?
A: Pentapeptide-1 enhances skin barrier function by stimulating the synthesis of barrier proteins such as filaggrin, involucrin, and loricrin, accelerating lamellar body secretion and lipid reorganization. At the same time, it reduces inflammation by inhibiting the release of pro-inflammatory cytokines IL-6 and TNF-α and decreasing IL-17 expression. This dual action significantly reduces TEWL, strengthens barrier integrity, and calms sensitive skin (Source: SciPeptide; BenchChem; CI.GUIDE).
Q4:How does Pentapeptide-1 regulate skin immune responses and manage sensitive skin conditions?
A: Pentapeptide-1 is the active fragment of thymopoietin (a human hormone with immunomodulating properties). It regulates skin microflora, reduces IL-17 expression, and controls helper T‑cell subsets (CD4⁺, Th17). In a 2024 animal study, topical thymopentin reduced epidermal thickness, inflammatory cell infiltration, and NF‑κB pathway expression while modulating skin microbiota (PMID: 38984208). These mechanisms make it effective for atopic dermatitis, contact dermatitis, psoriasis, and chronically sensitive skin (Source: CI.GUIDE; AusHealthIngredients).
GENOPEP GROUP | The Engine of Your Peptide Innovation
GENOPEP Group is a leading global peptide technology solutions provider, specializing in R&D, manufacturing, and commercialization in the fields of skin science and biopharmaceuticals. Supported by advanced scientific capabilities and a fully integrated supply chain, we deliver efficient and reliable innovation support to skincare brands worldwide.
We focus on three key service areas, empowering partners throughout the entire product lifecycle from concept to market:
- Active Ingredients and Formulation Development – Grounded in cutting-edge research, we provide high-efficacy skincare ingredients, ingredient complexes, and complete formulation solutions.
- End-to-End Production Support – Covering the full journey from lab-scale R&D and pilot optimization to commercial manufacturing, ensuring consistent product quality and reliable supply.
- Custom Synthesis Services – With strong capabilities in novel molecule development, we specialize in the design, synthesis, and preparation of peptide-based novel ingredients and related reference standards.
We believe in technology-driven products and collaboration-driven value. GENOPEP is not just a supplier—we are your trusted innovation partner, dedicated to co-creating the next generation of skincare solutions with you.
