Pentapeptide-59 Basic Chemical Information

Field Name	Basic information
INCI Name	Pentapeptide-59
CAS No.	N/A
Synonyms	SensAmone P5; Arg-Arg-Arg-Phe-Val ;RRRFV
Key Benefits	Sensitive Skin Care / Soothing & Anti-Inflammatory

Pentapeptide-59 Powder Specification

Field Name	Basic information
Form	Powder
Appearance	White to off-white powder
Purity (HPLC)	≥ 95.0%, or ≥ 98.0%
Storage Conditions	Store sealed, protected from light and moisture. Long-term storage at -20°C is recommended.
Packaging	Glass/plastic sample bottles, or customized packages based on special requests.
Shipping	Express air freight with moisture-proof protection.
Inquiry	[Request a Quote / Order Samples]

Pentapeptide-59 Solution Specification

Field Name	Specification Details
Form	Liquid
Appearance	Clear Transparent Liquid
Peptide Content	500ppm – 1000ppm (Customizable)
Storage Conditions	Can transport at room temperature. Store in a dry, dark place at 2-8°C for long term storage.
Packaging	1Kg or 5kg, or customized packages based on special requests.
Inquiry	[Request a Quote / Order Samples]

Pentapeptide-59: TRPV1 inhibitor from sea anemone. Reduces redness, itching & sensitivity. Prevents premature aging. SensAmone P5.

Advantage and Benefit

Feature	Details
TRPV1 Targeted Inhibition	Directly blocks overactive TRPV1 pain receptors (80% inhibition in vitro), eliminating the root cause of sensitive skin reactions like itching and burning.
Superior Soothing Efficacy	Clinically proven to reduce skin sensitivity, redness, and reactivity in placebo‑controlled studies, offering fast and lasting relief.
Neurocosmetic Compatibility	Ideal for sensitive skin care and neurocosmetics, providing anti‑inflammatory benefits without irritation or side effects.

FAQs

Q1.What advantages does Pentapeptide-59 offer for sensitive skin care formulations compared to traditional soothing agents?

A:Pentapeptide-59 (RRRFV) targets the root cause of sensitive skin—overactive TRPV1 pain receptors—by blocking them with high selectivity. In vitro, it inhibits TRPV1 activation by 80%, outperforming the full‑length sea anemone protein. Placebo‑controlled studies confirm reduced itching, burning, redness, and skin reactivity.

Q2:How exactly does Pentapeptide-59 work to reduce skin sensitivity at the molecular level?

A: Pentapeptide-59 is a synthetic peptide that mimics a sea anemone venom protein. It specifically binds to and inhibits the overactive TRPV1 pain receptor in the skin. By blocking this receptor, it neutralizes the signals that cause itching, stinging, and burning sensations, effectively calming reactive skin. In vitro studies show it inhibits TRPV1 activation by 80%.

Q3. What is the connection between Pentapeptide-59, TRPV1 inhibition, and anti-aging?

A: TRPV1 receptors are overexpressed in photoaged skin, and their continuous activation upregulates enzymes that destroy collagen, leading to premature skin aging. By inhibiting this overactive TRPV1 receptor, Pentapeptide-59 helps break this chain of events, protecting the skin‘s collagen network and preventing the formation of premature wrinkles and other signs of aging.

Q4. Can Pentapeptide-59 also help to reduce visible redness and signs of sensitization?

A: Yes. Clinical studies on skin show that Pentapeptide-59 effectively reduces signs of sensitization, which includes a visibly noticeable reduction in skin redness. It accomplishes this by calming the skin‘s overreactive response to environmental triggers and minimizing the skin’s overall stress response, leading to a more even, less irritated complexion.

Q5. How does Pentapeptide-59 compare to the full-length sea anemone protein APHC1 in efficacy?

A: The full-length APHC1 protein is too large to penetrate skin and is unstable for cosmetic use. The synthetic Pentapeptide-59 solves this by being smaller and more stable. Research shows it is more effective than the full protein: Pentapeptide-59 inhibited TRPV1 receptor activation by 80%, while the full-length APHC1 achieved only 25% inhibition in the same molecular concentration.