Hexapeptide-2 Basic Information

Field Name	Basic information
INCI Name	Hexapeptide-2
CAS No.	87616-84-0
Synonyms	L-Histidyl-D-tryptophyl-L-alanyl-L-tryptophyl-D-phenylalanyl-L-lysinamide; Growth hormone-releasing peptide 6; His-D-Trp-Ala-Trp-D-Phe-Lys-NH2; Dermostatyl™ IS
Key Benefits	Anti-pigmentation/Brightening/Anti-Wrinkle/ Anti Aging

Hexapeptide-2 Powder Specification

Field Name	Basic information
Form	Powder
Appearance	White to off-white powder
Purity (HPLC)	≥ 95%, or ≥ 98%
Storage Conditions	Store sealed, protected from light and moisture. Long-term storage at -20°C is recommended.
Packaging	Glass/plastic sample bottles, or customized packages based on special requests.
Shipping	Express air freight with moisture-proof protection.
Inquiry	[Request a Quote / Order Samples]

Hexapeptide-2 Solution Specification

Field Name	Basic information
Form	Liquid
Appearance	Clear Transparent Liquid
Peptide Content	1000 ppm, 500 ppm (Customizable upon request)
Storage Conditions	Can transport at room temperature. Store in a dry, dark place at 2-8°C for long term storage.
Packaging	1Kg or 5kg, or customized packages based on special requests.
Shipping	Express air freight with moisture-proof protection.
Sample	Request a Quote / Order Samples

Hexapeptide-2: α-MSH antagonist & miRNA dual action. Reduces hyperpigmentation and wrinkles. Clinically proven.

Advantage and Benefit

Feature	Details
α-MSH Antagonism	Competitively blocks MC1-R on melanocytes, preventing α-MSH binding and reducing melanin synthesis and transfer.
Epigenetic Whitening	Upregulates miR-218 to suppress pigmentation-related enzymes, providing gene-level control of hyperpigmentation.
Anti-Wrinkle via miRNA	Downregulates miR-29 to boost collagen I & III synthesis, improving skin firmness and reducing fine lines.
Tyrosinase Inhibition	Directly inhibits tyrosinase activity, complementing receptor blockade for dual-pathway melanin suppression.

FAQs

Q1: How does Hexapeptide-2 “interrupt” the skin tanning process?

A: Hexapeptide-2 acts as a competitive antagonist for theα-MSH receptor (MC1-R) on melanocytes. It literally “races” to the receptor and occupies it first. Since the “tanning signal” (α-MSH) cannot dock at its station, the melanocyte remains inactive and does not receive the command to produce melanin.

Q2: Is Hexapeptide-2 different from traditional whitening agents like Vitamin C?

A: Yes. Most whitening agents (like Vit C or Arbutin) focus on inhibiting the Tyrosinase enzyme after the signal has already been sent. Hexapeptide-2 works much earlier—at the signaling stage. It stops the melanin production process before it even starts, making it a “pre-emptive” whitening solution.

Q3: Can it help with existing age spots and hyperpigmentation?

A: Absolutely. By consistently blocking new melanin signals, it prevents dark spots from getting darker while the skin’s natural turnover process sheds existing pigmented cells. Over time, this leads to a visible fading of hyperpigmentation and a significantly more even skin tone.

Q4: Is Hexapeptide-2 safe for after-sun care?

A: It is an ideal ingredient for after-sun formulations. Sunlight triggers a surge of $\alpha$-MSH in the skin. Hexapeptide-2 steps in to neutralize this “emergency signal,” calming the melanocytes and preventing post-inflammatory hyperpigmentation (PIH) caused by UV exposure.

Q5: Why is it often combined with other anti-aging peptides?

A: While its primary job is brightening, its structure has a mild stimulating effect on skin vitality. More importantly, brightening the skin reduces the “visual age” of a person. Combining it with firming peptides like Hexapeptide-9 creates a “Global Anti-Aging” effect—addressing both structural wrinkles and pigment-related aging.