Professional Cosmetics Peptide Supplier | GENOPEP
Acetyl Tetrapeptide-40 (CAS: 1472633-28-5) Soothing and Anti-Inflammatory Peptides
PRODUCT PARAMETERS
Description
Acetyl Tetrapeptide-40 Basic Information
| Field Name | Basic information |
| INCI Name | Acetyl Tetrapeptide-40 |
| CAS No. | 1472633-28-5 |
| Synonyms | Acetyl Tetrapeptide-40; Telangyn; L-Threonine, N-acetyl-L-alanyl-L-threonyl-L-asparaginyl- |
| Key Benefits | Soothing and Anti-Inflammatory/ Sensitive Skin Care |
Acetyl Tetrapeptide-40 Powder Specifications
| Field Name | Basic information |
| Form | Powder |
| Appearance | White to off-white powder |
| Purity (HPLC) | ≥ 95%, or ≥ 98% |
| Storage Conditions | Store sealed, protected from light and moisture. Long-term storage at -20°C is recommended. |
| Packaging | Glass/plastic sample bottles, or customized packages based on special requests. |
| Shipping | Express air freight with moisture-proof protection. |
| Inquiry | [Request a Quote / Order Samples] |
Acetyl Tetrapeptide-40 Solution Specifications
| Field Name | Specification Details |
| Form | Liquid |
| Appearance | Clear Transparent Liquid |
| Peptide Content | 500ppm – 1000ppm (Customizable) |
| Storage Conditions | Can transport at room temperature. Store in a dry, dark place at 2-8°C for long term storage. |
| Packaging | 1Kg or 5kg, or customized packages based on special requests. |
| Inquiry | [Request a Quote / Order Samples] |
Acetyl Tetrapeptide-40: LL-37 modulator, anti-redness & anti-inflammatory. Clinically reduces erythema 19% (2%, 4 weeks). Telangyn™.
Advantage and Benefit
| Feature | Details |
| LL‑37 Anti‑Inflammatory Action | Reduces LL‑37‑driven release of IL‑6/IL‑8, decreasing facial redness, dilated capillaries, and inflammation‑related tissue degradation. |
| Photoprotection & MMP Inhibition | Modulates UV‑induced inflammation, prevents MMP upregulation, and preserves collagen for maintained firmness and elasticity. |
| DEJ & Structural Reinforcement | Stimulates laminin‑5, collagen VII, and syndecan‑1, strengthening dermal‑epidermal cohesion and skin resilience. |
| Clinically Proven Redness Reduction | 2% Telangyn™ reduced erythema by 19.2% and redness by 17.7% in 4 weeks (Personal Care Magazine, 2012). |
FAQs
Q1: How does Acetyl Tetrapeptide-40 specifically target skin redness?
A: It addresses the root cause of redness by inhibiting the release of pro-inflammatory cytokines, specifically Interleukin-6 (IL-6) and Interleukin-8 (IL-8). By regulating these signals, it calms the “inflammatory cascade” that leads to vasodilation and visible skin flushing.
Q2: What is the connection between Cathelicidins (LL-37) and this peptide?
A: Overexpression of the antimicrobial peptide LL-37 is a known trigger for rosacea and chronic irritation. Acetyl Tetrapeptide-40 modulates the skin’s response to LL-37, preventing it from triggering the excessive inflammation that manifests as erythema and dilated capillaries (telangiectasia).
Q3: Can it be used for Post-Inflammatory Hyperpigmentation (PIH)?
A: Yes. By preventing excessive inflammation and regulating UV-induced melanogenesis, it effectively reduces the intensity of dark spots that typically form after a breakout or skin injury, leading to a more even and calm skin tone.
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GENOPEP Group is a leading global peptide technology solutions provider, specializing in R&D, manufacturing, and commercialization in the fields of skin science and biopharmaceuticals. Supported by advanced scientific capabilities and a fully integrated supply chain, we deliver efficient and reliable innovation support to skincare brands worldwide.
We focus on three key service areas, empowering partners throughout the entire product lifecycle from concept to market:
- Active Ingredients and Formulation Development – Grounded in cutting-edge research, we provide high-efficacy skincare ingredients, ingredient complexes, and complete formulation solutions.
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