Professional Cosmetics Peptide Supplier | GENOPEP
Hexapeptide-3（CAS:1205679-02-2） Anti-Wrinkle Peptide
PRODUCT PARAMETERS
Description
Hexapeptide-3 Basic Information
| Field Name | Basic information |
| INCI Name | Hexapeptide-3 |
| CAS No. | 1205679-02-2 |
| Synonyms | (3S)-4-[[(2S)-1-[(2S)-2-[[(1S,2R)-1-carboxy-2-hydroxypropyl]carbamoyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]amino]-3-[[(2S)-2-[[(2S)-2,6-diaminohexanoyl]amino]-4-methylpentanoyl]amino]-4-oxobutanoic acid, Ala-Asp-Leu-Lys-Pro-Thr, ADLKPT |
| Key Benefits | Anti-Wrinkle / Anti Aging/ Lip Plumping |
Hexapeptide-3 Powder Specification
| Field Name | Basic information |
| Form | Powder |
| Appearance | White to off-white powder |
| Purity (HPLC) | ≥ 95%, or ≥ 98% |
| Storage Conditions | Store sealed, protected from light and moisture. Long-term storage at -20°C is recommended. |
| Packaging | Glass/plastic sample bottles, or customized packages based on special requests. |
| Shipping | Express air freight with moisture-proof protection. |
| Inquiry | [Request a Quote / Order Samples] |
Hexapeptide-3 Solution Specification
| Field Name | Basic information |
| Form | Liquid |
| Appearance | Clear Transparent Liquid |
| Peptide Content | 1000 ppm, 500 ppm (Customizable upon request) |
| Storage Conditions | Can transport at room temperature. Store in a dry, dark place at 2-8°C for long term storage. |
| Packaging | 1Kg or 5kg, or customized packages based on special requests. |
| Shipping | Express air freight with moisture-proof protection. |
| Sample | Request a Quote / Order Samples |
Hexapeptide-3: fibronectin-mimetic peptide boosts ECM, collagen, cell adhesion. Clinically proven anti-wrinkle & lip plumping.
Advantage and Benefit
| Feature | Details |
| Fibronectin Mimicry | Mimics fibronectin to promote laminin-5 and β1 integrin expression, strengthening cell-ECM binding for tissue remodeling and repair. |
| Integrin Upregulation | Enhances genes responsible for integrin synthesis, improving dermal-ECM adhesion and restoring structural organization for anti-aging effects. |
| Collagen Activation | Activates TGF-β signaling in fibroblasts to stimulate type I & III collagen synthesis (21% increase), improving firmness and reducing wrinkles. |
| Neurotransmitter Inhibition | Acetylated form inhibits acetylcholine release and SNARE complex formation, reducing dynamic wrinkles like crow’s feet and forehead lines. |
FAQs
Q1. What is the exact sequence and CAS number of Hexapeptide-3?
Answer: Hexapeptide-3 has the amino acid sequence Ala-Asp-Leu-Lys-Pro-Thr (ADLKPT). Its CAS number is 1205679-02-2. This synthetic peptide is a biomimetic fragment derived from fibronectin.
Q2. How does Hexapeptide-3 improve skin firmness and reduce wrinkles?
Answer: Hexapeptide-3 mimics fibronectin to promote cell adhesion and ECM remodeling. It upregulates integrin synthesis, activates TGF-β signaling, and stimulates type I and III collagen production, increasing firmness while reducing fine lines and wrinkles.
Q3.What are the recommended formulation conditions for Hexapeptide-3 stability?
Answer: For optimal stability, maintain pH between 5.5 and 7.0. Add Hexapeptide-3 at temperatures below 40°C. Avoid strong acids/bases, high-valent metal ions (Fe³⁺, Cu²⁺), and prolonged heating. Store raw material at 2–8°C.
Q4. Does Hexapeptide-3 have clinical evidence for lip plumping and anti-aging?
Answer: Yes. Clinical data show Hexapeptide-3 increases VEGF expression in lip mucosa, inducing capillary neogenesis and increasing lip thickness by 15–20%. Studies also confirm wrinkle reduction (30–48.9%) and improved skin barrier function.
GENOPEP GROUP | The Engine of Your Peptide Innovation
GENOPEP Group is a leading global peptide technology solutions provider, specializing in R&D, manufacturing, and commercialization in the fields of skin science and biopharmaceuticals. Supported by advanced scientific capabilities and a fully integrated supply chain, we deliver efficient and reliable innovation support to skincare brands worldwide.
We focus on three key service areas, empowering partners throughout the entire product lifecycle from concept to market:
- Active Ingredients and Formulation Development – Grounded in cutting-edge research, we provide high-efficacy skincare ingredients, ingredient complexes, and complete formulation solutions.
- End-to-End Production Support – Covering the full journey from lab-scale R&D and pilot optimization to commercial manufacturing, ensuring consistent product quality and reliable supply.
- Custom Synthesis Services – With strong capabilities in novel molecule development, we specialize in the design, synthesis, and preparation of peptide-based novel ingredients and related reference standards.
We believe in technology-driven products and collaboration-driven value. GENOPEP is not just a supplier—we are your trusted innovation partner, dedicated to co-creating the next generation of skincare solutions with you.
