Professional Cosmetics Peptide Supplier | GENOPEP
Palmitoyl Hexapeptide-14（CAS:891498-01-4） Anti-wrinkle Peptide
PRODUCT PARAMETERS
Description
Palmitoyl Hexapeptide-14 Basic Information
| Field Name | Basic information |
| INCI Name | Palmitoyl Hexapeptide-14 |
| CAS No. | 891498-01-4 |
| Synonyms | Granactive AGE (Grant Industries), Granactive Hexapeptide, InvisaSkin Matrix Rebuilder‑O, Granactive Powder 168‑EL, Pal‑Phe‑Ala‑Leu‑Leu‑Lys‑Leu‑NH₂ |
| Key Benefits | Anti-wrinkle/Anti-Aging |
Palmitoyl Hexapeptide-14 Powder Specification
| Field Name | Basic information |
| Form | Powder |
| Appearance | White to off-white powder |
| Purity (HPLC) | ≥ 95%, or ≥ 98% |
| Storage Conditions | Store sealed, protected from light and moisture. Long-term storage at -20°C is recommended. |
| Packaging | Glass/plastic sample bottles, or customized packages based on special requests. |
| Shipping | Express air freight with moisture-proof protection. |
| Inquiry | [Request a Quote / Order Samples] |
Palmitoyl Hexapeptide-14 Solution Specification
| Field Name | Basic information |
| Form | Liquid |
| Appearance | Clear Transparent Liquid |
| Peptide Content | 1000 ppm, 500 ppm (Customizable upon request) |
| Storage Conditions | Can transport at room temperature. Store in a dry, dark place at 2-8°C for long term storage. |
| Packaging | 1Kg or 5kg, or customized packages based on special requests. |
| Shipping | Express air freight with moisture-proof protection. |
| Sample | Request a Quote / Order Samples |
Palmitoyl Hexapeptide-14: TGF-β signal peptide. Boosts collagen 156%, inhibits MMPs. Comparable to 0.05% tretinoin without irritation.
Advantage and Benefit
| Feature | Details |
| Fibroblast Activation via TGF‑β | Binds to fibroblast receptors and activates TGF‑β signalling, driving biosynthesis of collagen I/III/IV and elastin for dermal redensification. |
| Triple MMP Inhibition (MMP‑1/‑3/‑9) | Selectively suppresses MMP‑1 by 68%, protecting both newly formed and existing collagen from enzymatic degradation. |
| Tretinoin‑Equivalent Efficacy | 12‑week clinical trial shows Palmitoyl Hexapeptide-14 matches 0.05% tretinoin in wrinkle reduction but without irritation or photosensitivity. |
| Clinically Proven Multi‑Benefit | Reduces wrinkle depth 42%, improves smoothness 37%, boosts elasticity 49%, increases skin density 58% and firmness 45%. |
FAQs
Q1:How does Palmitoyl Hexapeptide-14 achieve anti‑wrinkle effects comparable to tretinoin?
A: Palmitoyl Hexapeptide-14 acts as a potent cell-communicating messenger. It mimics the natural signals that Tretinoin (Retinoic Acid) sends to the cell nucleus to stimulate fibroblast proliferation and collagen biosynthesis. However, it does so via a non-irritating matrikine pathway, providing the same structural rejuvenation without the inflammatory side effects.
Q2:Why is its role in inhibiting MMP-9 so critical?
A: Collagen degradation is primarily driven by enzymes called MMPs. MMP-9 is specifically destructive to the dermal framework. By inhibiting MMP-9, Palmitoyl Hexapeptide-14 acts as a “Collagen Shield,” preventing the premature breakdown of newly synthesized fibers and ensuring long-lasting firmness.
GENOPEP GROUP | The Engine of Your Peptide Innovation
GENOPEP Group is a leading global peptide technology solutions provider, specializing in R&D, manufacturing, and commercialization in the fields of skin science and biopharmaceuticals. Supported by advanced scientific capabilities and a fully integrated supply chain, we deliver efficient and reliable innovation support to skincare brands worldwide.
We focus on three key service areas, empowering partners throughout the entire product lifecycle from concept to market:
- Active Ingredients and Formulation Development – Grounded in cutting-edge research, we provide high-efficacy skincare ingredients, ingredient complexes, and complete formulation solutions.
- End-to-End Production Support – Covering the full journey from lab-scale R&D and pilot optimization to commercial manufacturing, ensuring consistent product quality and reliable supply.
- Custom Synthesis Services – With strong capabilities in novel molecule development, we specialize in the design, synthesis, and preparation of peptide-based novel ingredients and related reference standards.
We believe in technology-driven products and collaboration-driven value. GENOPEP is not just a supplier—we are your trusted innovation partner, dedicated to co-creating the next generation of skincare solutions with you.
