Professional Cosmetics Peptide Supplier | GENOPEP
Palmitoyl Hexapeptide-12（CAS: 171263-26-6）Anti-Aging Peptide
PRODUCT PARAMETERS
Description
Palmitoyl Hexapeptide-12 Basic Information
| Field Name | Basic information |
| INCI Name | Palmitoyl Hexapeptide-12 |
| CAS No. | 171263-26-6 |
| Synonyms | Palmitoyl Hexapeptide; Palmitoyl-Val-Gly-Val-Ala-Pro-Gly-OH; 2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-(hexadecanoylamino)-3-methylbutanoyl]amino]acetyl]amino]-3-methylbutanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]acetic acid |
| Key Benefits | Anti Aging/ Anti-Wrinkle/ Barrier Repair |
Palmitoyl Hexapeptide-12 Powder Specification
| Field Name | Basic information |
| Form | Powder |
| Appearance | White to off-white powder |
| Purity (HPLC) | ≥ 95%, or ≥ 98% |
| Storage Conditions | Store sealed, protected from light and moisture. Long-term storage at -20°C is recommended. |
| Packaging | Glass/plastic sample bottles, or customized packages based on special requests. |
| Shipping | Express air freight with moisture-proof protection. |
| Inquiry | [Request a Quote / Order Samples] |
Palmitoyl Hexapeptide-12 Solution Specification
| Field Name | Basic information |
| Form | Liquid |
| Appearance | Clear Transparent Liquid |
| Peptide Content | 1000 ppm, 500 ppm (Customizable upon request) |
| Storage Conditions | Can transport at room temperature. Store in a dry, dark place at 2-8°C for long term storage. |
| Packaging | 1Kg or 5kg, or customized packages based on special requests. |
| Shipping | Express air freight with moisture-proof protection. |
| Sample | Request a Quote / Order Samples |
Palmitoyl Hexapeptide-12: elastin fragment matrikine. Boosts collagen, elastin, fibronectin. Reduces IL-6. Clinically proven anti-aging.
Advantage and Benefit
| Feature | Details |
| Elastin Fragment Matrikine | Mimics natural elastin-derived signals to instruct fibroblasts for ECM repair and remodeling. |
| Palmitoyl Enhanced Penetration | Lipophilic modification boosts stratum corneum permeation and prolongs dermal activity. |
| ECM Protein Upregulation | Stimulates synthesis of collagen I/III, elastin, fibronectin, and GAGs to restore firmness. |
| Anti‑Inflammatory Protection | Reduces IL‑6 production, limiting inflammation‑driven collagen/elastin degradation. |
FAQs
Q1: What is the key difference between Palmitoyl Hexapeptide-12 and non-palmitoylated Hexapeptide-12 in formulations?
Answer: Palmitoylation adds a fatty acid chain, which significantly improves skin penetration and stability. While Hexapeptide-12 alone is a water-soluble signal peptide, Palmitoyl Hexapeptide-12 has enhanced ability to reach the dermis and deliver stronger, longer-lasting anti-aging effects.
Q2. English: What are the optimal pH and temperature conditions for formulating Palmitoyl Hexapeptide-12?
Answer: The peptide is stable at pH 5.0–7.0 and should be added below 40°C during manufacturing. Avoid strong acids (pH <4), strong bases, and prolonged heating above 50°C to prevent degradation. Store raw material at 2–8°C.
Q3. English: Can Palmitoyl Hexapeptide-12 be combined with retinol or vitamin C in anti-aging formulas?
Answer: Yes, it is compatible with most actives including retinol, vitamin C derivatives, niacinamide, and hyaluronic acid. However, avoid direct combination with high concentrations of pure L-ascorbic acid at low pH (<4) as extreme acidity may degrade the peptide.
Q4. English: What clinical evidence supports the anti-wrinkle efficacy of Palmitoyl Hexapeptide-12?
Answer: A double-blind study on 10 female volunteers using 4% Palmitoyl Hexapeptide-12 showed improvements in skin elasticity, firmness, and complexion. The CIR panel also confirmed its safety. It stimulates collagen I/III and elastin while reducing IL-6.
GENOPEP GROUP | The Engine of Your Peptide Innovation
GENOPEP Group is a leading global peptide technology solutions provider, specializing in R&D, manufacturing, and commercialization in the fields of skin science and biopharmaceuticals. Supported by advanced scientific capabilities and a fully integrated supply chain, we deliver efficient and reliable innovation support to skincare brands worldwide.
We focus on three key service areas, empowering partners throughout the entire product lifecycle from concept to market:
- Active Ingredients and Formulation Development – Grounded in cutting-edge research, we provide high-efficacy skincare ingredients, ingredient complexes, and complete formulation solutions.
- End-to-End Production Support – Covering the full journey from lab-scale R&D and pilot optimization to commercial manufacturing, ensuring consistent product quality and reliable supply.
- Custom Synthesis Services – With strong capabilities in novel molecule development, we specialize in the design, synthesis, and preparation of peptide-based novel ingredients and related reference standards.
We believe in technology-driven products and collaboration-driven value. GENOPEP is not just a supplier—we are your trusted innovation partner, dedicated to co-creating the next generation of skincare solutions with you.
